Global burden of liver disease: 2023 update
Liver disease accounts for two million deaths annually and is responsible for 4% of all
deaths (1 out of every 25 deaths worldwide); approximately two-thirds of all liver-related …
deaths (1 out of every 25 deaths worldwide); approximately two-thirds of all liver-related …
Cirrhosis-associated immune dysfunction
A Albillos, R Martin-Mateos, S Van der Merwe… - Nature Reviews …, 2022 - nature.com
The term cirrhosis-associated immune dysfunction (CAID) comprises the distinctive
spectrum of immune alterations associated with the course of end-stage liver disease …
spectrum of immune alterations associated with the course of end-stage liver disease …
EASL Clinical Practice Guidelines for the management of patients with decompensated cirrhosis
P Angeli, M Bernardi, C Villanueva, C Francoz… - Journal of …, 2018 - Elsevier
The natural history of cirrhosis is characterised by an asymptomatic compensated phase
followed by a decompensated phase, marked by the development of overt clinical signs, the …
followed by a decompensated phase, marked by the development of overt clinical signs, the …
[HTML][HTML] Outcomes following SARS-CoV-2 infection in patients with chronic liver disease: an international registry study
Background & Aims Chronic liver disease (CLD) and cirrhosis are associated with immune
dysregulation, leading to concerns that affected patients may be at risk of adverse outcomes …
dysregulation, leading to concerns that affected patients may be at risk of adverse outcomes …
EASL Clinical Practice Guidelines on the management of hepatic encephalopathy
S Montagnese, PE Rautou, M Romero-Gómez… - Journal of …, 2022 - Elsevier
Summary The EASL Clinical Practice Guidelines (CPGs) on the management of hepatic
encephalopathy (HE) present evidence-based answers to a set of relevant questions (where …
encephalopathy (HE) present evidence-based answers to a set of relevant questions (where …
[HTML][HTML] The PREDICT study uncovers three clinical courses of acutely decompensated cirrhosis that have distinct pathophysiology
Background & Aims Acute decompensation (AD) of cirrhosis is defined as the acute
development of ascites, gastrointestinal hemorrhage, hepatic encephalopathy, infection or …
development of ascites, gastrointestinal hemorrhage, hepatic encephalopathy, infection or …
Acute-on-chronic liver failure clinical guidelines
In patients with cirrhosis and chronic liver disease, acute-on-chronic liver failure is emerging
as a major cause of mortality. These guidelines indicate the preferred approach to the …
as a major cause of mortality. These guidelines indicate the preferred approach to the …
[PDF][PDF] Systemic inflammation in decompensated cirrhosis: characterization and role in acute‐on‐chronic liver failure
J Clària, RE Stauber, MJ Coenraad, R Moreau… - …, 2016 - Wiley Online Library
Acute‐on‐chronic liver failure (ACLF) in cirrhosis is characterized by acute decompensation
(AD), organ failure (s), and high short‐term mortality. Recently, we have proposed (systemic …
(AD), organ failure (s), and high short‐term mortality. Recently, we have proposed (systemic …
Acute-on-chronic liver failure: an update
Acute-on-chronic liver failure (ACLF) is a syndrome characterised by acute decompensation
of chronic liver disease associated with organ failures and high short-term mortality. Alcohol …
of chronic liver disease associated with organ failures and high short-term mortality. Alcohol …
[HTML][HTML] PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis
Background & Aims Acute decompensation (AD) of cirrhosis may present without acute-on-
chronic liver failure (ACLF)(AD-No ACLF), or with ACLF (AD-ACLF), defined by organ failure …
chronic liver failure (ACLF)(AD-No ACLF), or with ACLF (AD-ACLF), defined by organ failure …