Nuclear receptors (NRs) are ligand-activated transcription factors sharing a common
evolutionary history and having similar sequence features at the protein level. Selective …

Antiretrovirals are prone to drug-drug and drug-food interactions that can result in
subtherapeutic or supratherapeutic concentrations. Interactions between antiretrovirals and …

Pregnane X Receptor (PXR), a member of the nuclear receptor (NR) superfamily, is
expressed in liver and intestine, as also in other tissues and cells. PXR is activated by a …

Human pregnane X receptor (hPXR) plays a key role in regulating metabolism and
clearance of endogenous and exogenous substances. Identification of novel hPXR …

Importance of the field: Despite the efficacy of combination antiretroviral therapy (ART), a
large proportion of patients living with HIV/AIDS on ART does not achieve or maintain …

The nucleoside reverse transcriptase inhibitors lamivudine and zidovudine and the protease
inhibitors lopinavir and ritonavir are currently used in anti‐human immunodeficiency virus …

Therapeutic drug monitoring is pivotal to improve the management of HIV infection. Here, a
new HPLC–UV method to quantify simultaneously maraviroc and raltegravir levels in human …

Pregnane X Receptor (PXR) is a member of the nuclear receptor superfamily, expressed in
liver, intestine and other tissues. PXR exerts transcriptional regulation by binding to its DNA …

For drugs with a narrow therapeutic index, therapeutic drug monitoring methods are
essential for patient management. Although immunoassays are commercially available for …

Saliva may provide interesting advantages as matrix for compliance measurements,
pharmacokinetic studies and therapeutic drug monitoring in resource limited countries. We …