Toll-like receptor (TLR) agonists as a driving force behind next-generation vaccine adjuvants and cancer therapeutics

A Kaur, J Baldwin, D Brar, DB Salunke… - Current opinion in …, 2022 - Elsevier
Until recently, the development of new human adjuvants was held back by a poor
understanding of their mechanisms of action. The field was revolutionized by the discovery …

Recent advances in mRNA cancer vaccines: meeting challenges and embracing opportunities

B Wang, J Pei, S Xu, J Liu, J Yu - Frontiers in immunology, 2023 - frontiersin.org
Since the successful application of messenger RNA (mRNA) vaccines in preventing COVID-
19, researchers have been striving to develop mRNA vaccines for clinical use, including …

Next-generation Vaccine Development with nanomaterials: recent advances, possibilities, and challenges

S Shetty, PC Alvarado, D Pettie… - Annual Review of …, 2024 - annualreviews.org
Nanomaterials are becoming important tools for vaccine development owing to their tunable
and adaptable nature. Unique properties of nanomaterials afford opportunities to modulate …

Covax-19/Spikogen® vaccine based on recombinant spike protein extracellular domain with Advax-CpG55. 2 adjuvant provides single dose protection against SARS …

L Li, Y Honda-Okubo, J Baldwin, R Bowen… - Vaccine, 2022 - Elsevier
COVID-19 presents an ongoing global health crisis. Protein-based COVID-19 vaccines that
are well-tolerated, safe, highly-protective and convenient to manufacture remain of major …

Data-driven analytics leveraging artificial intelligence in the era of COVID-19: an insightful review of recent developments

A Majeed, SO Hwang - Symmetry, 2021 - mdpi.com
This paper presents the role of artificial intelligence (AI) and other latest technologies that
were employed to fight the recent pandemic (ie, novel coronavirus disease-2019 (COVID …

Transforming aquaculture through vaccination: A review on recent developments and milestones

I Tammas, K Bitchava, AI Gelasakis - Vaccines, 2024 - mdpi.com
Aquaculture has rapidly emerged as one of the fastest growing industries, expanding both
on global and on national fronts. With the ever-increasing demand for proteins with a high …

Revolutionizing adjuvant development: harnessing AI for next-generation cancer vaccines

WY Zhang, XL Zheng, PS Coghi, JH Chen… - Frontiers in …, 2024 - frontiersin.org
With the COVID-19 pandemic, the importance of vaccines has been widely recognized and
has led to increased research and development efforts. Vaccines also play a crucial role in …

Advax-CpG55. 2-adjuvanted monovalent or trivalent SARS-CoV-2 recombinant spike protein vaccine protects hamsters against heterologous infection with Beta or …

Y Honda-Okubo, R Bowen, M Barker… - Vaccine, 2023 - Elsevier
The ongoing evolution of SARS-CoV-2 variants emphasizes the need for vaccines providing
broad cross-protective immunity. This study was undertaken to assess the ability of Advax …

Development and use of machine learning algorithms in vaccine target selection

B Bravi - npj Vaccines, 2024 - nature.com
Computer-aided discovery of vaccine targets has become a cornerstone of rational vaccine
design. In this article, I discuss how Machine Learning (ML) can inform and guide key …

[HTML][HTML] mRNA therapeutics: New vaccination and beyond

HH Wei, L Zheng, Z Wang - Fundamental Research, 2023 - Elsevier
The idea of mRNA therapy had been conceived for decades before it came into reality
during the Covid-19 pandemic. The mRNA vaccine emerges as a powerful and general tool …