Photoreceptor cells and RPE contribute to the development of diabetic retinopathy

D Tonade, TS Kern - Progress in retinal and eye research, 2021 - Elsevier
Diabetic retinopathy (DR) is a leading cause of blindness. It has long been regarded as
vascular disease, but work in the past years has shown abnormalities also in the neural …

Presence and risk factors for glaucoma in patients with diabetes

BJ Song, LP Aiello, LR Pasquale - Current diabetes reports, 2016 - Springer
Diabetes mellitus represents a growing international public health issue with a near
quadrupling in its worldwide prevalence since 1980. Though it has many known …

Diabetic retinopathy: from animal models to cellular signaling

PM Pitale, MS Gorbatyuk - International Journal of Molecular Sciences, 2022 - mdpi.com
Diabetic retinopathy (DR) is an ocular complication of diabetes mellitus (DM), a metabolic
disorder characterized by elevation in blood glucose level. The pathogenesis of DR includes …

Diabetic retinal neurodegeneration as a form of diabetic retinopathy

D Soni, P Sagar, B Takkar - International Ophthalmology, 2021 - Springer
Purpose To review the evidence supporting diabetic retinal neurodegeneration (DRN) as a
form of diabetic retinopathy. Method Review of literature. Results DRN is recognized to be a …

Visual dysfunction in diabetes

ED Eggers - Annual review of vision science, 2023 - annualreviews.org
Although diabetic retinopathy (DR) is clinically diagnosed as a vascular disease, many
studies find retinal neuronal and visual dysfunction before the onset of vascular DR. This …

The effects of early diabetes on inner retinal neurons

ED Eggers, TA Carreon - Visual neuroscience, 2020 - cambridge.org
Diabetic retinopathy is now well understood as a neurovascular disease. Significant deficits
early in diabetes are found in the inner retina that consists of bipolar cells that receive inputs …

Tauroursodeoxycholic acid alleviates endoplasmic reticulum stress-mediated visual deficits in diabetic tie2-TNF transgenic mice via TGR5 signaling

R Lenin, KA Jha, J Gentry, A Shrestha… - Journal of Ocular …, 2023 - liebertpub.com
Purpose: This study evaluated if tauroursodeoxycholic acid (TUDCA) alleviates pro-
inflammatory and endoplasmic reticulum (ER) stress-mediated visual deficits in diabetic tie2 …

[HTML][HTML] Dopamine deficiency mediates early rod-driven inner retinal dysfunction in diabetic mice

MK Kim, MH Aung, L Mees, DE Olson… - … & visual science, 2018 - jov.arvojournals.org
Purpose: Electroretinograms (ERGs) are abnormal in diabetic retinas before the appearance
of vascular lesions, providing a possible biomarker for diabetic vision loss. Previously, we …

Long-term functional and structural consequences of primary blast overpressure to the eye

RS Allen, CT Motz, A Feola, KC Chesler… - Journal of …, 2018 - liebertpub.com
Acoustic blast overpressure (ABO) injury in military personnel and civilians is often
accompanied by delayed visual deficits. However, most animal model studies dealing with …

ON-type retinal ganglion cells are preferentially affected in STZ-induced diabetic mice

RZ Cui, L Wang, SN Qiao, YC Wang… - … & Visual Science, 2019 - iovs.arvojournals.org
Purpose: We investigate morphologic and physiologic alterations of ganglion cells (GCs) in
a streptozocin (STZ)-induced diabetic mouse model. Methods: Experiments were conducted …