Drug resistance represents a major obstacle in cancer management, and the mechanisms
underlying stress adaptation of cancer cells in response to therapy-induced hostile …

Metformin is the most used drug for type 2 diabetes (T2DM). Its antitumor activity has been
described by clinical studies showing reduced risk of cancer development in T2DM patients …

The drug development process, especially of antineoplastic agents, has become
increasingly costly and ineffective. Drug repurposing and drug combination are alternatives …

Background The biguanide metformin has been shown to not only reduce circulating
glucose levels but also suppress in vitro and in vivo growth of prostate cancer. However, the …

Inadequate sustained immune activation and tumor recurrence are major limitations of
radiotherapy (RT), sustained and targeted activation of the tumor microenvironment can …

Epidemiological evidence has accentuated the repurposing of metformin hydrochloride for
cancer treatment. However, the extreme hydrophilicity and poor permeability of metformin …

High levels of heme oxygenase (HO)-1 have been frequently reported in different human
cancers, playing a major role in drug resistance and regulation of cancer cell redox …

Background: Valproic acid/sodium valproate (VPA), a well-known anti-epileptic agent,
inhibits histone deacetylases, induces histone hyperacetylation, promotes DNA …

In this review, we discuss the functions and main effects on pregnancy outcomes of three
agents that have the ability to induce epigenetic modifications: valproic acid (VPA), a well …

Abstract Purpose of Review Metformin is widely used for the management of pre-diabetes
and type 2 diabetes (T2D). In recent times, metformin has also been the focus of intensive …