The ability to sense physical forces is conserved across all organisms. Cells convert
mechanical stimuli into electrical or chemical signals via mechanically activated ion …

Mechanical force is an essential physical element that contributes to the formation and
function of life. The discovery of the evolutionarily conserved PIEZO family, including PIEZO1 …

Mechanical load of the skeleton system is essential for the development, growth, and
maintenance of bone. However, the molecular mechanism by which mechanical stimuli are …

Mechanotransduction is a fundamental ability that allows living organisms to receive and
respond to physical signals from both the external and internal environments. The …

Physical forces are ubiquitous in biological processes across scales and diverse contexts.
This review highlights the significance of mechanical forces in nervous system development …

Nerve injury leads to chronic pain and exaggerated sensitivity to gentle touch (allodynia) as
well as a loss of sensation in the areas in which injured and non-injured nerves come …

Mechanical damage is one of the predisposing factors of inflammation, and it runs through
the entire inflammatory pathological process. Repeated or persistent damaging mechanical …

Muscle stem cells (MuSCs) are essential for tissue homeostasis and regeneration, but the
potential contribution of MuSC morphology to in vivo function remains unknown. Here, we …

The evolutionarily conserved Piezo channel family, including Piezo1 and Piezo2 in
mammals, serves as versatile mechanotransducers in various cell types and consequently …

Activation of mechanosensitive ion channels underlies a variety of fundamental
physiological processes that require sensation of mechanical force. Different …