Based on engineered or bacterial nucleases, the development of genome editing
technologies has opened up the possibility of directly targeting and modifying genomic …

Retinitis Pigmentosa (RP) is a hereditary retinopathy that affects about 2.5 million people
worldwide. It is characterized with progressive loss of rods and cones and causes severe …

Many forms of blindness result from the dysfunction or loss of retinal photoreceptors.
Induced pluripotent stem cells (iPSCs) hold great potential for the modelling of these …

INTRODUCTION Cone photoreceptors in the human retina enable daytime, color, and high-
acuity vision. The three subtypes of human cones are defined by the visual pigment that they …

The advantages of using induced pluripotent stem cells (iPSCs) instead of embryonic stem
(ES) cells in regenerative medicine centre around circumventing concerns about the ethics …

Inherited retinal degenerative diseases, a genetically and phenotypically heterogeneous
group of disorders, affect the function of photoreceptor cells and are among the leading …

Irreversible blindness caused by loss of photoreceptors may be amenable to cell therapy.
We previously demonstrated retinal repair and restoration of vision through transplantation …

Cell replacement therapy is a promising treatment for irreversible retinal cell death in diverse
diseases, such as age-related macular degeneration (AMD), Stargardt's disease, retinitis …

Retinal neurodegeneration associated with the dysfunction or death of photoreceptors is a
major cause of incurable vision loss. Tremendous progress has been made over the last two …

The mammalian retina displays no intrinsic regenerative capacities, therefore retinal
degenerative diseases such as age-related macular degeneration (AMD) or retinitis …