Genome-wide association studies (GWASs) have enabled the discovery of common genetic
variation contributing to normal and pathological traits and clinical drug responses, but …

Future advances in plant genomics will make it possible to scan a genome for
polymorphisms associated with qualitative and quantitative traits. Before this potential can …

The vast majority of genome-wide association study (GWAS) risk loci fall in non-coding
regions of the genome. One possible hypothesis is that these GWAS risk loci alter the …

Association map** (AM) is a powerful tool for fine map** complex trait variation down to
nucleotide sequences by exploiting historical recombination events. A major problem in AM …

The human genome holds an extraordinary trove of information about human development,
physiology, medicine and evolution. Here we report the results of an international …

In this review, we describe recent empirical and theoretical work on the extent of linkage
disequilibrium (LD) in the human genome, comparing the predictions of simple population …

With the availability of a dense genome-wide map of single nucleotide polymorphisms
(SNPs), a central issue in human genetics is whether it is now possible to use linkage …

Particular alleles at neighbouring loci tend to be co-inherited. For tightly linked loci, this
might lead to associations between alleles in the population—a property known as linkage …

Dense marker genotypes allow the construction of the realized relationship matrix between
individuals, with elements the realized proportion of the genome that is identical by descent …

Assembling a comprehensive catalog of common human sequence polymorphisms is a key
goal of the Human Genome Project. The International SNP Map Working Group has …