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Structure and activity of nanozymes: Inspirations for de novo design of nanozymes
Nanozymes, nanomaterials with enzyme-like activities, are becoming powerful competitors
and potential substitutes for natural enzymes because of their excellent performance …
and potential substitutes for natural enzymes because of their excellent performance …
Recent trends in protein and peptide-based biomaterials for advanced drug delivery
Engineering protein and peptide-based materials for drug delivery applications has gained
momentum due to their biochemical and biophysical properties over synthetic materials …
momentum due to their biochemical and biophysical properties over synthetic materials …
Precision conjugation: An emerging tool for generating protein–polymer conjugates
X Liu, W Gao - Angewandte Chemie International Edition, 2021 - Wiley Online Library
Protein–polymer conjugates are increasingly being applied in biomedicine because of the
unique combination of the biological activity of the proteins and the multifunctionality and …
unique combination of the biological activity of the proteins and the multifunctionality and …
Recent and future perspectives on engineering interferons and other cytokines as therapeutics
As crucial mediators and regulators of our immune system, cytokines are involved in a broad
range of biological processes and are implicated in various disease pathologies. The field of …
range of biological processes and are implicated in various disease pathologies. The field of …
piSTING: A Pocket‐Independent Agonist Based on Multivalency‐Driven STING Oligomerization
SH Zhuo, TY Wang, L Zhao, JY Su, JJ Hu… - Angewandte …, 2024 - Wiley Online Library
The stimulator of interferon genes (STING) pathway is a potent therapeutic target for innate
immunity. Despite the efforts to develop pocket‐dependent small‐molecule STING agonists …
immunity. Despite the efforts to develop pocket‐dependent small‐molecule STING agonists …
Design and pharmaceutical evaluation of bifunctional fusion protein of FGF21 and GLP-1 in the treatment of nonalcoholic steatohepatitis
X Ye, Y Chen, J Qi, S Zhu, Y Wu, J **ong, F Hu… - European Journal of …, 2023 - Elsevier
Abstract Fibroblast growth factor 21 (FGF21) and glucagon-like peptide-1 (GLP-1) may be
useful for the treatment of type 2 diabetes, obesity, and non-alcoholic fatty liver disease …
useful for the treatment of type 2 diabetes, obesity, and non-alcoholic fatty liver disease …
Cytokine conjugates to elastin-like polypeptides
L Gong, Z Yang, F Zhang, W Gao - Advanced Drug Delivery Reviews, 2022 - Elsevier
Cytokines are a group of pleiotropic proteins which are crucial for various biological
processes and useful as therapeutics. However, they usually suffer from the poor stability …
processes and useful as therapeutics. However, they usually suffer from the poor stability …
Thermoresponsive Polypeptide Fused L‐Asparaginase with Mitigated Immunogenicity and Enhanced Efficacy in Treating Hematologic Malignancies
S Zhang, Y Sun, L Zhang, F Zhang, W Gao - Advanced Science, 2023 - Wiley Online Library
L‐Asparaginase (ASP) is well‐known for its excellent efficacy in treating hematological
malignancies. Unfortunately, the intrinsic shortcomings of ASP, namely high …
malignancies. Unfortunately, the intrinsic shortcomings of ASP, namely high …
An ultra-long-acting L-asparaginase synergizes with an immune checkpoint inhibitor in starvation-immunotherapy of metastatic solid tumors
S Zhang, L Gong, Y Sun, F Zhang, W Gao - Biomaterials, 2025 - Elsevier
Metastasis stands as the primary contributor to mortality associated with tumors.
Chemotherapy and immunotherapy are frequently utilized in the management of metastatic …
Chemotherapy and immunotherapy are frequently utilized in the management of metastatic …
Thermoresponsive and protease‐cleavable interferon‐polypeptide conjugates with spatiotemporally programmed two‐step release kinetics for tumor therapy
Z Wang, J Guo, J Sun, P Liang, Y Wei… - Advanced …, 2019 - Wiley Online Library
Protein‐polymer conjugates show improved pharmacokinetics but reduced bioactivity and
tumor penetration as compared to native proteins, resulting in limited antitumor efficacy. To …
tumor penetration as compared to native proteins, resulting in limited antitumor efficacy. To …