Structure and activity of nanozymes: Inspirations for de novo design of nanozymes

Z Wang, R Zhang, X Yan, K Fan - Materials Today, 2020 - Elsevier
Nanozymes, nanomaterials with enzyme-like activities, are becoming powerful competitors
and potential substitutes for natural enzymes because of their excellent performance …

Recent trends in protein and peptide-based biomaterials for advanced drug delivery

A Varanko, S Saha, A Chilkoti - Advanced drug delivery reviews, 2020 - Elsevier
Engineering protein and peptide-based materials for drug delivery applications has gained
momentum due to their biochemical and biophysical properties over synthetic materials …

Precision conjugation: An emerging tool for generating protein–polymer conjugates

X Liu, W Gao - Angewandte Chemie International Edition, 2021 - Wiley Online Library
Protein–polymer conjugates are increasingly being applied in biomedicine because of the
unique combination of the biological activity of the proteins and the multifunctionality and …

Recent and future perspectives on engineering interferons and other cytokines as therapeutics

T Aung, WS Grubbe, RJ Nusbaum… - Trends in biochemical …, 2023 - cell.com
As crucial mediators and regulators of our immune system, cytokines are involved in a broad
range of biological processes and are implicated in various disease pathologies. The field of …

piSTING: A Pocket‐Independent Agonist Based on Multivalency‐Driven STING Oligomerization

SH Zhuo, TY Wang, L Zhao, JY Su, JJ Hu… - Angewandte …, 2024 - Wiley Online Library
The stimulator of interferon genes (STING) pathway is a potent therapeutic target for innate
immunity. Despite the efforts to develop pocket‐dependent small‐molecule STING agonists …

Design and pharmaceutical evaluation of bifunctional fusion protein of FGF21 and GLP-1 in the treatment of nonalcoholic steatohepatitis

X Ye, Y Chen, J Qi, S Zhu, Y Wu, J **ong, F Hu… - European Journal of …, 2023 - Elsevier
Abstract Fibroblast growth factor 21 (FGF21) and glucagon-like peptide-1 (GLP-1) may be
useful for the treatment of type 2 diabetes, obesity, and non-alcoholic fatty liver disease …

Cytokine conjugates to elastin-like polypeptides

L Gong, Z Yang, F Zhang, W Gao - Advanced Drug Delivery Reviews, 2022 - Elsevier
Cytokines are a group of pleiotropic proteins which are crucial for various biological
processes and useful as therapeutics. However, they usually suffer from the poor stability …

Thermoresponsive Polypeptide Fused L‐Asparaginase with Mitigated Immunogenicity and Enhanced Efficacy in Treating Hematologic Malignancies

S Zhang, Y Sun, L Zhang, F Zhang, W Gao - Advanced Science, 2023 - Wiley Online Library
L‐Asparaginase (ASP) is well‐known for its excellent efficacy in treating hematological
malignancies. Unfortunately, the intrinsic shortcomings of ASP, namely high …

An ultra-long-acting L-asparaginase synergizes with an immune checkpoint inhibitor in starvation-immunotherapy of metastatic solid tumors

S Zhang, L Gong, Y Sun, F Zhang, W Gao - Biomaterials, 2025 - Elsevier
Metastasis stands as the primary contributor to mortality associated with tumors.
Chemotherapy and immunotherapy are frequently utilized in the management of metastatic …

Thermoresponsive and protease‐cleavable interferon‐polypeptide conjugates with spatiotemporally programmed two‐step release kinetics for tumor therapy

Z Wang, J Guo, J Sun, P Liang, Y Wei… - Advanced …, 2019 - Wiley Online Library
Protein‐polymer conjugates show improved pharmacokinetics but reduced bioactivity and
tumor penetration as compared to native proteins, resulting in limited antitumor efficacy. To …