Insulin resistance in polycystic ovary syndrome across various tissues: an updated review of pathogenesis, evaluation, and treatment

H Zhao, J Zhang, X Cheng, X Nie, B He - Journal of Ovarian Research, 2023‏ - Springer
Polycystic ovary syndrome (PCOS) is a common endocrine disorder characterized by
chronic ovulation dysfunction and overabundance of androgens; it affects 6–20% of women …

Deconstructing a syndrome: genomic insights into PCOS causal mechanisms and classification

M Dapas, A Dunaif - Endocrine reviews, 2022‏ - academic.oup.com
Polycystic ovary syndrome (PCOS) is among the most common disorders in women of
reproductive age, affecting up to 15% worldwide, depending on the diagnostic criteria …

The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions

N Rahmioglu, S Mortlock, M Ghiasi, PL Møller… - Nature …, 2023‏ - nature.com
Endometriosis is a common condition associated with debilitating pelvic pain and infertility.
A genome-wide association study meta-analysis, including 60,674 cases and 701,926 …

[HTML][HTML] The role of Glp-1 receptor agonists in insulin resistance with concomitant obesity treatment in polycystic ovary syndrome

K Bednarz, K Kowalczyk, M Cwynar, D Czapla… - International journal of …, 2022‏ - mdpi.com
Insulin resistance is documented in clamp studies in 75% of women with polycystic ovary
syndrome (PCOS). Although it is not included in the diagnostic criteria of PCOS, there is a …

The prevalence of polycystic ovary syndrome in reproductive-aged women of different ethnicity: a systematic review and meta-analysis

T Ding, PJ Hardiman, I Petersen, FF Wang, F Qu… - …, 2017‏ - pmc.ncbi.nlm.nih.gov
The prevalence of PCOS was investigated in many studies in different continents. However,
there is no established prevalence of PCOS for distinct ethnic groups. In the current analysis …

Polycystic ovary syndrome: an evolutionary adaptation to lifestyle and the environment

J Parker, C O'brien, J Hawrelak, FL Gersh - International Journal of …, 2022‏ - mdpi.com
Polycystic ovary syndrome (PCOS) is increasingly recognized as a complex metabolic
disorder that manifests in genetically susceptible women following a range of negative …

Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism

Y Sapkota, V Steinthorsdottir, AP Morris… - Nature …, 2017‏ - nature.com
Endometriosis is a heritable hormone-dependent gynecological disorder, associated with
severe pelvic pain and reduced fertility; however, its molecular mechanisms remain largely …

Genetics of human female infertility

SA Yatsenko, A Rajkovic - Biology of reproduction, 2019‏ - academic.oup.com
About 10% of women of reproductive age are unable to conceive or carry a pregnancy to
term. Female factors alone account for at least 35% of all infertility cases and comprise a …

Sex, microbes, and polycystic ovary syndrome

VG Thackray - Trends in Endocrinology & Metabolism, 2019‏ - cell.com
Recent studies have shown that sex and sex steroids influence the composition of the gut
microbiome. These studies also indicate that steroid regulation of the gut microbiome may …

[HTML][HTML] An update of genetic basis of PCOS pathogenesis

RP Crespo, TASS Bachega, BB Mendonça… - … of endocrinology and …, 2018‏ - SciELO Brasil
Polycystic ovary syndrome (PCOS) is a common and complex endocrine disorder that
affects 5-20% of reproductive age women. PCOS clinical symptoms include hirsutism …