Despite significant progress in antibiotic discovery, millions of lives are lost annually to
infections. Surprisingly, the failure of antimicrobial treatments to effectively eliminate …

Background Allergic fungal rhinosinusitis (AFRS) is an endotype of chronic rhinosinusitis
(CRS) with nasal polyps characterized by eosinophilic mucin laden with fungal hyphae …

Antibiotic failure can be defined as any clinical situation where treatment with antibiotics fails
to cure the patient and remove the infection. Genetically-determined antibiotic resistance …

Chronic rhinosinusitis (CRS) is characterized by immune dysfunction, mucus
hypersecretion, and persistent infection of the paranasal sinuses. While Staphylococcus …

The unified airway refers to the combined upper and lower airways and their shared
pathophysiologic relationships. These 2 systems are thought to be interconnected, and …

Chronic rhinosinusitis (CRS) is a debilitating condition characterized by long-lasting
inflammation of the paranasal sinuses. It affects a significant portion of the population …

Background In a gene expression analysis comparing sinus mucosa samples from allergic
fungal rhinosinusitis (AFRS) patients with samples from non-AFRS chronic rhinosinusitis …

Cationic host defense peptides (HDPs) are a promising alternative to antibiotics in the fight
against Staphylococcus aureus infections. In this study, we investigated the antibacterial and …

With the growing interest in develo** silver-based antimicrobials, there is a need to better
understand the behavior of silver within biological systems. To address this, we showed that …

Rhinosinusitis is a common inflammatory disease of the sinonasal mucosa and paranasal
sinuses. The pathogenesis of rhinosinusitis involves a variety of factors, including genetics …