Galectin-3 (Gal-3) regulates basic cellular functions such as cell–cell and cell–matrix
interactions, growth, proliferation, differentiation, and inflammation. It is not surprising …

Galectins are a family of carbohydrate-binding proteins with an affinity for β-galactosides.
Galectin-1 (Gal-1) is differentially expressed by various normal and pathological tissues and …

Galectins are a family of proteins that bind to specific glycans thereby deciphering the
information captured within the glycome. In the last two decades, several galectin family …

Galectins are glycan-binding proteins that contain one or two carbohydrate domains and
mediate multiple biological functions. By analyzing clinical tumor samples, the abnormal …

Despite the existence of tumor-specific immune cells, most tumors have devised strategies
to avoid immune attack. We demonstrate here that galectin-1 (Gal-1), a negative regulator of …

Biomarkers are vital in healthcare as they provide valuable insights into disease diagnosis,
prognosis, treatment response, and personalized medicine. They serve as objective …

An intact immune system is essential to prevent the development and progression of
neoplastic cells in a process termed immune surveillance. During this process the innate …

This review discusses the role of galectin-1 in the tumor microenvironment. First, the
structure and function of galectin-1 are discussed. Galectin-1, a member of the galectin …

The major hurdle for cancer vaccines to be effective is posed by tumor immune evasion.
Several common immune mechanisms and mediators are exploited by tumors to avoid …

Purpose To identify a 15-KDa novel hypoxia-induced secreted protein in head and neck
squamous cell carcinomas (HNSCC) and to determine its role in malignant progression …