There are more than 2 million bone grafting procedures performed annually in the US alone.
Despite significant efforts, the repair of large segmental bone defects is a substantial clinical …

Bone is a remarkable tissue that can respond to external stimuli. The importance of
mechanical forces on the mass and structural development of bone has long been accepted …

The pore size of porous scaffold plays a critical role in bone regeneration, but its mechanism
and optimal value remain unclear. This study investigated the effect of pore size on …

Critically engineered stiffness and strength of a scaffold are crucial for managing
maladapted stress concentration and reducing stress shielding. At the same time, suitable …

Abstract Bone Tissue Engineering has been focusing on improving the current methods for
bone repair, being the use of scaffolds presented as an upgrade to traditional surgery …

Most of our knowledge of bone cell physiology is derived from experiments carried out in
vitro on polystyrene substrates. However, these traditional monolayer cell cultures do not …

In bone tissue engineering research, bioreactors designed for replicating the main features
of the complex native environment represent powerful investigation tools. Moreover, when …

In bone tissue engineering experiments, fluid-induced shear stress is able to stimulate cells
to produce mineralised extracellular matrix (ECM). The application of shear stress on …

Biomaterials are dynamic tools with many applications: from the primitive use of bone and
wood in the replacement of lost limbs and body parts, to the refined involvement of smart …

In the treatment of osseous defects micro-structured three-dimensional materials for bone
replacement serve as leading structure for cell migration, proliferation and bone formation …