In order to meet the high energy demand, a metabolic reprogramming occurs in cancer cells.
Its role is crucial in promoting tumor survival. Among the substrates in demand, oxygen is …

The ability to efficiently adapt metabolism by substrate sensing, trafficking, storage, and
utilization, dependent on availability and requirement, is known as metabolic flexibility. In …

These guidelines are a consensus work of a considerable number of members of the
immunology and flow cytometry community. They provide the theory and key practical …

From a technical point of view a flow cytometer is a light detection device capable of
detecting photons of different wavelengths over a high dynamic range. In order to achieve a …

Immune checkpoint therapy has resulted in remarkable improvements in the outcome for
certain cancers. To broaden the clinical impact of checkpoint targeting, we devised a …

Natural killer (NK) cells are lymphocytes with important anti-tumour functions. Cytokine
activation of NK cell glycolysis and oxidative phosphorylation (OXPHOS) are essential for …

Immune cells are highly dynamic in terms of their growth, proliferation, and effector functions
as they respond to immunological challenges. Different immune cells can adopt distinct …

Hypoxia is a hallmark of inflamed, infected or damaged tissue, and the adaptation to
inadequate tissue oxygenation is regulated by hypoxia-inducible factors (HIFs). HIFs are key …

Immune activated T lymphocytes modulate the activity of key metabolic pathways to support
the transcriptional reprograming and resha** of cell proteomes that permits effector T cell …

Neutrophils provide first line of host defense against bacterial infections utilizing glycolysis
for their effector functions. How glycolysis and its major byproduct lactate are triggered in …