The bacterial cell wall is composed of a highly crosslinked matrix of glycopeptide polymers
known as peptidoglycan that dictates bacterial cell morphology and protects against …

Methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pyogenes (group A
streptococcus [GrAS]) cause serious and sometimes fatal human diseases. They are among …

The trillions of bacteria that make up the human microbiome are believed to encode
functions that are important to human health; however, little is known about the specific …

During growth and division, the bacterial cell wall is remodeled, resulting in the liberation of
peptidoglycan (PG) fragments which are typically reinternalized and recycled. Recycling of …

We discovered that Enterococcus faecium (E. faecium), a ubiquitous commensal bacterium,
and its secreted peptidoglycan hydrolase (SagA) were sufficient to enhance intestinal barrier …

The target range of a bacterial secretion system can be defined by effector substrate
specificity or by the efficacy of effector delivery. Here, we report the crystal structure of Tse1 …

The type VI secretion system (T6SS) is a contact-dependent contractile multiprotein
apparatus widely distributed in Gram-negative bacteria. These systems can deliver different …

Background Bacteriophages encode endolysins to lyse their host cell and allow escape of
their progeny. Endolysins are also active against Gram-positive bacteria when applied from …

The type VI secretion system (T6SS), a multisubunit needle-like apparatus, has recently
been found to play a role in interspecies interactions. The Gram-negative bacteria harboring …

The success of Mycobacterium tuberculosis in sustaining long-term survival within the host
macrophages partly relies on its unique cell envelop that also confers low susceptibility to …