Biological processes are often dynamic, thus researchers must monitor their activity at
multiple time points. The most abundant source of information regarding such dynamic …

When normal tissue and tumour samples are compared by microarray analysis, the biggest
differences most often occur in the expression levels of genes that control cell proliferation …

Data on absolute molecule numbers will empower the modeling, understanding, and
comparison of cellular functions and biological systems. We quantified transcriptomes and …

The degradation of undesirable cellular components or organelles, including invading
microbes, by autophagy is crucial for cell survival. Here, Shigella, an invasive bacteria, was …

We used fluorescence microscopy to measure global and local concentrations of 28
cytoskeletal and signaling proteins fused to yellow fluorescent protein (YFP) in the fission …

We show that genes with rapidly changing expression levels in response to stress contain
significantly lower intron densities in yeasts, thale cress and mice. Therefore, we propose …

The cell cycle, over which cells grow and divide, is a fundamental process of life. Its
dysregulation has devastating consequences, including cancer,–. The cell cycle is driven by …

The eukaryotic cell division cycle is a highly regulated process that consists of a complex
series of events and involves thousands of proteins. Researchers have studied the …

Many different approaches have been developed to model and simulate gene regulatory
networks. We proposed the following categories for gene regulatory network models …

In metazoans, cyclin-dependent kinase 7 (CDK7) has essential roles in both the cell-division
cycle and transcription, as a CDK-activating kinase (CAK) and as a component of the …