Chronic (continuous, non-interrupted) hypoxia and cycling (intermittent, transient) hypoxia
are two types of hypoxia occurring in malignant tumors. They are both associated with the …

Adenosine monophosphate-activated protein kinase (AMPK) is a significant energy sensor
in the maintenance of cellular energy homeostasis. Autophagy is a highly conserved …

AMP-activated protein kinase (AMPK) is known as a pivotal cellular energy sensor,
mediating the adaptation to low energy levels by deactivating anabolic processes and …

Arsenic is widely available in the environment and arsenic toxicity is a public health problem
of serious concern worldwide. Zingerone is a promising phytochemical with various …

Ischemia‐reperfusion injury (IRI) refers to a syndrome in which tissue damage is further
aggravated and organ function further deteriorates when blood flow is restored after a period …

Previous studies show that notoginsenoside R1 (NG-R1), a novel saponin isolated from
Panax notoginseng, protects kidney, intestine, lung, brain and heart from ischemia …

Metformin, a well‐known AMPK agonist, has been widely used as the first‐line drug for
treating type 2 diabetes. There had been a significant concern regarding the use of …

Aging is an important risk factor for cardiovascular diseases, and aging‐related cardiac
dysfunction serves as a major determinant of morbidity and mortality in elderly populations …

Metabolic interventions via targeting intratumoral dysregulated metabolism pathways have
shown promise in reinvigorating antitumor immunity. However, approved small molecule …

Owing to the distinctive constituents of tumor tissue from those healthy organs,
nanomedicine strategies show significant potentials in smart drug delivery. Nowadays …