Candida albicans is a major fungal pathogen of humans. It exists as a commensal in the oral
cavity, gut or genital tract of most individuals, constrained by the local microbiota, epithelial …

Systemic fungal infections pose a serious clinical problem. Treatment options are limited,
and antifungal drug resistance is increasing. In addition, a substantial proportion of patients …

Candida albicans is both a member of the healthy human microbiome and a major pathogen
in immunocompromised individuals. Infections are typically treated with azole inhibitors of …

TAC1, a Candida albicans transcription factor situated near the mating-type locus on
chromosome 5, is necessary for the upregulation of the ABC-transporter genes CDR1 and …

Candida albicans has an elaborate, yet efficient, mating system that promotes conjugation
between diploid a and α strains. The product of mating is a tetraploid a/α cell that must …

Acquired azole resistance is a serious clinical problem that is often associated with the
appearance of aneuploidy and, in particular, with the formation of an isochromosome [i (5L)] …

The genomic plasticity of Candida albicans, a commensal and common opportunistic fungal
pathogen, continues to reveal unexpected surprises. Once thought to be asexual, we now …

ABSTRACT TAC1 (for transcriptional activator of CDR genes) is critical for the upregulation
of the ABC transporters CDR1 and CDR2, which mediate azole resistance in Candida …

The fungal disease chytridiomycosis, caused by Batrachochytrium dendrobatidis, is
enigmatic because it occurs globally in both declining and apparently healthy (non …

Forced interspecific hybridization has been used in yeasts for many years to study
speciation or to construct artificial strains with novel fermentative and metabolic properties …