Tubulin/HDAC dual-target inhibitors: Insights from design strategies, SARs, and therapeutic potential
Z Zhang, R Su, J Liu, K Chen, C Wu, P Sun… - European Journal of …, 2024 - Elsevier
Microtubules, one of the cytoskeletons in eukaryotic cells, maintain the proper operation of
several cellular functions. Additionally, they are regulated by the acetylation of HDAC6 and …
several cellular functions. Additionally, they are regulated by the acetylation of HDAC6 and …
Dual-targeting inhibitors involving tubulin for the treatment of cancer
PA Yakkala, A Kamal - Bioorganic Chemistry, 2024 - Elsevier
Combination therapies play a pivotal role in cancer treatment due to the intricate nature of
the disease. Tubulin, a protein crucial for cellular functions, is a prime target in tumor therapy …
the disease. Tubulin, a protein crucial for cellular functions, is a prime target in tumor therapy …
An experimental and computational exploration on synthesis, structural elucidation, weaker interaction and anticancer activity analysis of novel progesterone …
Progesterone oxadiazole (PRODAZ) derivative was synthesized by substituting the α-
hydrogen of acetyl progesterone with iodine and reacting with DMSO and isoniazid. Modern …
hydrogen of acetyl progesterone with iodine and reacting with DMSO and isoniazid. Modern …
Synergistic effect of new pyrimidine derivative with oxacilin against methicillin-resistant Staphylococcus aureus
BK de Oliveira Silva, ZS do Monte… - Future Medicinal …, 2024 - Taylor & Francis
Aim: This work aimed to synthesize a new pyrimidine PYB01 with potential application
against antimicrobial resistance. Materials & methods: PYB01 was synthesized through …
against antimicrobial resistance. Materials & methods: PYB01 was synthesized through …
4-methyl-N-[5-[Phenylamino] Acetyl]-2-yl] Benzenesulfonamides: Synthesis, Characterization, and Preliminary Biological Evaluation
Introduction Oxazole and the compounds containing sulphonamides are utilized for various
treatments of microbial disease as well as for diabetic patients. In the current study, the …
treatments of microbial disease as well as for diabetic patients. In the current study, the …