The concept of an epigenetic landscape describing potential cellular fates arising from
pluripotent cells, first advanced by Conrad Waddington, has evolved in light of experiments …

Signaling by the extracellular signal-regulated kinase (ERK) pathway controls many cellular
processes, including cell division, death, and differentiation. In this second installment of a …

Transcriptional regulation in metazoans occurs through long-range genomic contacts
between enhancers and promoters, and most genes are transcribed in episodic" bursts" of …

Cells are a fundamental unit of biological organization, and identifying them in imaging data–
cell segmentation–is a critical task for various cellular imaging experiments. While deep …

RNA is the fundamental information transfer system in the cell. The ability to follow single
messenger RNAs (mRNAs) from transcription to degradation with fluorescent probes gives …

While it has been established that the responses of T cells to antigens are combinatorially
regulated by multiple signaling pathways, it remains elusive what mechanisms cells utilize to …

Many natural transcription factors are regulated in a pulsatile fashion, but it remains
unknown whether synthetic gene expression systems can benefit from such dynamic …

The MYC oncogene has been studied for decades, yet there is still intense debate over how
this transcription factor controls gene expression. Here, we seek to answer these questions …

Recent advancements in single-cell and single-molecule imaging technologies have
resolved biological processes in time and space that are fundamental to understanding the …

ERK signaling regulates the expression of target genes, but it is unclear how ERK activity
dynamics are interpreted. Here, we investigate this question using simultaneous, live, single …