Conventional cancer therapy strategies, although centered around killing tumor cells, often
lead to severe side effects on surrounding normal tissues, thus compromising the chronic …

Pharmacological vitamin C (VC) has gained attention for its pro-oxidant characteristics and
selective ability to induce cancer cell death. However, defining its role in cancer has been …

Background Patients with metastatic pancreatic ductal adenocarcinoma (PDAC) have poor 5-
year survival. Pharmacological ascorbate (P-AscH-, high dose, intravenous, vitamin C) has …

Ataxia Telangiectasia–mutated (ATM) inhibitors are being developed as radiosensitizers to
improve the antitumor effects of radiotherapy, but ATM inhibition can also radiosensitize …

Vitamin C is a water-soluble vitamin, and is contained in many vegetables, fruits and other
foods. Vitamin C possesses many bioactivities, such as antioxidantand anticanceractivities …

Purpose: Resistance to radiation is a major factor responsible for treatment failure and the
relapse of many cancers. ATM inhibitors are being developed as radiosensitizers to improve …