Numerous drug treatments that have recently entered the clinic or clinical trials have their
genesis in zebrafish. Zebrafish are well established for their contribution to developmental …

Growing evidence demonstrates that circulating tumor DNA (ctDNA) minimal residual
disease (MRD) following treatment for solid tumors predicts relapse. These results suggest …

A broad range of brain pathologies critically relies on the vasculature, and cerebrovascular
disease is a leading cause of death worldwide. However, the cellular and molecular …

The CNS critically relies on the formation and proper function of its vasculature during
development, adult homeostasis and disease. Angiogenesis—the formation of new blood …

Vascular and lymphatic malformations represent a challenge for clinicians. The identification
of inherited and somatic mutations in important signaling pathways, including the PI3K …

Intracerebral haemorrhage (ICH) is the second most common type of stroke and a major
cause of mortality and disability worldwide. Despite advances in surgical interventions and …

Stroke is an important cause of neurological morbidity in children; most survivors have
permanent neurological deficits that affect the remainder of their life. Stroke in childhood, the …

Somatic Mutations in “Benign” Disease DNA mutations occur in nearly every tissue
throughout the human life span and accumulate at various rates in different tissues …

Importance Mesial temporal lobe epilepsy (MTLE) is the most common focal epilepsy
subtype and is often refractory to antiseizure medications. While most patients with MTLE do …

KRAS gain-of-function mutations are frequently observed in sporadic arteriovenous
malformations. The mechanisms underlying the progression of such KRAS-driven …