Chemically Induced Dimerization via Nanobody Binding Facilitates in Situ Ligand Assembly and On-Demand GPCR Activation

SJ Saha, RW Cheloha - JACS Au, 2024 - ACS Publications
Methods that enable the on-demand synthesis of biologically active molecules offer the
potential for a high degree of control over the timing and context of target activation; …

Enhancing bone regeneration and osseointegration using rhPTH (1-34) and dimeric R25CPTH (1-34) in an osteoporotic beagle model

JO Shin, JB Lee, S Lee, JW Kim - Elife, 2024 - elifesciences.org
This study investigates the effects of two parathyroid hormone (PTH) analogs, rhPTH (1-34)
and dimeric R25C PTH (1-34), on bone regeneration and osseointegration in a …