Pathophysiology of acute respiratory distress syndrome and COVID-19 lung injury

KE Swenson, ER Swenson - Critical care clinics, 2021 - pmc.ncbi.nlm.nih.gov
The pathophysiology of acute respiratory distress syndrome (ARDS) is marked by
inflammation-mediated disruptions in alveolar-capillary permeability, edema formation …

Pulmonary surfactant: a mighty thin film

F Possmayer, YY Zuo, RAW Veldhuizen… - Chemical …, 2023 - ACS Publications
Pulmonary surfactant is a critical component of lung function in healthy individuals. It
functions in part by lowering surface tension in the alveoli, thereby allowing for breathing …

Mitochondria-targeted multifunctional nanoprodrugs by inhibiting metabolic reprogramming for combating cisplatin-resistant lung cancer

H Lu, W Tong, M Jiang, H Liu, C Meng, K Wang, X Mu - ACS nano, 2024 - ACS Publications
How to address the resistance of cisplatin (CDDP) has always been a clinical challenge.
The resistance mechanism of platinum-based drugs is very complex, including nuclear DNA …

[HTML][HTML] Inhaled aerosols: Their role in COVID-19 transmission, including biophysical interactions in the lungs

TR Sosnowski - Current Opinion in Colloid & Interface Science, 2021 - Elsevier
The high rate of spreading of COVID-19 is attributed to airborne particles exhaled by
infected but often asymptomatic individuals. In this review, the role of aerosols in SARS-CoV …

The role of sialidases in the pathogenesis of bacterial vaginosis and their use as a promising pharmacological target in bacterial vaginosis

L Chen, J Li, B **ao - Frontiers in Cellular and Infection Microbiology, 2024 - frontiersin.org
Bacterial vaginosis (BV) is an infection of the genital tract characterized by disturbance of the
normally Lactobacilli-dominated vaginal flora due to the overgrowth of Gardnerella and …

Glycocalyx curving the membrane: forces emerging from the cell exterior

JCH Kuo, MJ Paszek - Annual review of cell and developmental …, 2021 - annualreviews.org
Morphological transitions are typically attributed to the actions of proteins and lipids. Largely
overlooked in membrane shape regulation is the glycocalyx, a pericellular membrane coat …

Endothelial dysfunction triggers acute respiratory distress syndrome in patients with sepsis: a narrative review

R Cusack, LD Bos, P Povoa, I Martin-Loeches - Frontiers in Medicine, 2023 - frontiersin.org
Acute respiratory distress syndrome (ARDS) is a severe organ failure occurring mainly in
critically ill patients as a result of different types of insults such as sepsis, trauma or …

[HTML][HTML] The role of the alveolar epithelial glycocalyx in acute respiratory distress syndrome

AN Rizzo, EP Schmidt - American Journal of Physiology …, 2023 - journals.physiology.org
The alveolar epithelial glycocalyx is a dense anionic layer of glycosaminoglycans (GAGs)
and proteoglycans that lines the apical surface of the alveolar epithelium. In contrast to the …

Inter-alpha-trypsin inhibitor (IαI) and hyaluronan modifications enhance the innate immune response to influenza virus in the lung

F Tang, SR Reeves, JE Brune, MY Chang, CK Chan… - Matrix Biology, 2024 - Elsevier
The inter-alpha-trypsin inhibitor (IαI) complex is composed of the bikunin core protein with a
single chondroitin sulfate (CS) attached and one or two heavy chains (HCs) covalently …

Intraperitoneal aerosolized drug delivery: technology, recent developments, and future outlook

M Rahimi-Gorji, L Van de Sande, C Debbaut… - Advanced drug delivery …, 2020 - Elsevier
Current therapies for patients with peritoneal metastases (PM) are only moderately effective.
Recently, a novel locoregional treatment method for PM was introduced, consisting of a …