Two-component systems reprogramme diverse aspects of microbial physiology in response
to environmental cues. Canonical systems are composed of a transmembrane sensor …

Perceiving environmental and internal information and reacting in adaptive ways are
essential attributes of living organisms. Two-component systems are relevant protein …

Bacteria must constantly probe their environment for rapid adaptation, a crucial need most
frequently served by two-component systems (TCS). As one component, sensor histidine …

Two-component signal transduction systems (TCSs) are widely conserved in bacteria to
respond to and adapt to the changing environment. Since TCSs are also involved in …

Vancomycin-resistant enterococci (VRE) are a serious threat to human health, with few
treatment options being available. New therapeutics are urgently needed to relieve the …

The solute binding proteins (SBPs) of prokaryotes are present in the extracytosolic space.
Although their primary function is providing substrates to transporters, SBPs also stimulate …

Two‐component systems (TCS) constitute the predominant means by which prokaryotes
read out and adapt to their environment. Canonical TCSs comprise a sensor histidine kinase …

Microbial rhodopsins (MRs) are a large family of photoactive membrane proteins, found in
microorganisms belonging to all kingdoms of life, with new members being constantly …

Two-component systems (TCS) are widespread signaling systems present in all domains of
life. TCS typically consist of a signal receptor/transducer and a response regulator. The …

Two-component signaling systems (TCSs) are comprised of a sensory histidine kinase and
a response regulator protein. In response to environmental changes, sensor kinases directly …