Nanoparticle entry into cells; the cell biology weak link

G Griffiths, J Gruenberg, M Marsh, J Wohlmann… - Advanced Drug Delivery …, 2022 - Elsevier
Nanoparticles (NP) are attractive options for the therapeutic delivery of active
pharmaceutical drugs, proteins and nucleic acids into cells, tissues and organs. Research …

Emerging small molecule-engineered hybrid nanomedicines for cancer therapy

Y Chen, T Zhao, M Bai, T Gu, J Sun, Z He… - Chemical Engineering …, 2022 - Elsevier
Cancer should not be simply regarded as a single disease, but an intricate adaptive system
involved with inflammation, metabolism and immunization. Therefore, combination of two or …

Intranuclear nanoribbons for selective killing of osteosarcoma cells

S Liu, Q Zhang, H He, M Yi, W Tan… - Angewandte Chemie …, 2022 - Wiley Online Library
Herein, we show intranuclear nanoribbons formed upon dephosphorylation of leucine‐rich L‐
or D‐phosphopeptide catalyzed by alkaline phosphatase (ALP) to selectively kill …

Enzymatically forming intranuclear peptide assemblies for selectively killing human induced pluripotent stem cells

S Liu, Q Zhang, AN Shy, M Yi, H He… - Journal of the American …, 2021 - ACS Publications
Tumorigenic risk of undifferentiated human induced pluripotent stem cells (iPSCs), being a
major obstacle for clinical application of iPSCs, requires novel approaches for selectively …

Protease-responsive peptide-conjugated mitochondrial-targeting AIEgens for selective imaging and inhibition of SARS-CoV-2-infected cells

Y Cheng, AE Clark, J Zhou, T He, Y Li, RM Borum… - ACS …, 2022 - ACS Publications
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a serious threat to
human health and lacks an effective treatment. There is an urgent need for both real-time …

Magnetically induced brownian motion of iron oxide nanocages in alternating magnetic fields and their application for efficient SiRNA delivery

MA Kang, J Fang, A Paragodaarachchi, K Kodama… - Nano …, 2022 - ACS Publications
Hyperthermia of superparamagnetic nanoparticles driven by Néel relaxation in an
alternating magnetic field (AMF) has been studied in biomedical areas; however, Brownian …

An Amphiphilic Cell‐Penetrating Macrocycle for Efficient Cytosolic Delivery of Proteins, DNA, and CRISPR Cas9

SS Qutub, IA Bhat, BI Maatouk, B Moosa… - Angewandte Chemie …, 2024 - Wiley Online Library
The discovery of safe platforms that can circumvent the endocytic pathway is of great
significance for biological therapeutics that are usually degraded during endocytosis. Here …

Alkaline Phosphatase Enabled Fluorogenic Reaction and in situ Coassembly of Near-Infrared and Radioactive Nanoparticles for in vivo Imaging

Y Hu, Y Miao, J Zhang, Y Chen, L Qiu, J Lin, D Ye - Nano Letters, 2021 - ACS Publications
Smart near-infrared (NIR) fluorescence (FL) and positron emission tomography (PET)
bimodal probes have shown promise for preoperative and intraoperative imaging of tumors …

In situ stimulus-responsive self-assembled nanomaterials for drug delivery and disease treatment

Z Yan, Y Liu, L Zhao, J Hu, Y Du, X Peng, Z Liu - Materials Horizons, 2023 - pubs.rsc.org
The individual motifs that respond to specific stimuli for the self-assembly of nanomaterials
play important roles. In situ constructed nanomaterials are formed spontaneously without …

Cellular journey of nanomaterials: Theories, trafficking, and kinetics

X Wang, WX Wang - Aggregate, 2023 - Wiley Online Library
Engineered nanomaterials (NMs) are increasingly fabricated in various fields involving
consumer goods, waste management, and biomedical applications such as drug delivery …