Nanoparticle entry into cells; the cell biology weak link
Nanoparticles (NP) are attractive options for the therapeutic delivery of active
pharmaceutical drugs, proteins and nucleic acids into cells, tissues and organs. Research …
pharmaceutical drugs, proteins and nucleic acids into cells, tissues and organs. Research …
Emerging small molecule-engineered hybrid nanomedicines for cancer therapy
Y Chen, T Zhao, M Bai, T Gu, J Sun, Z He… - Chemical Engineering …, 2022 - Elsevier
Cancer should not be simply regarded as a single disease, but an intricate adaptive system
involved with inflammation, metabolism and immunization. Therefore, combination of two or …
involved with inflammation, metabolism and immunization. Therefore, combination of two or …
Intranuclear nanoribbons for selective killing of osteosarcoma cells
Herein, we show intranuclear nanoribbons formed upon dephosphorylation of leucine‐rich L‐
or D‐phosphopeptide catalyzed by alkaline phosphatase (ALP) to selectively kill …
or D‐phosphopeptide catalyzed by alkaline phosphatase (ALP) to selectively kill …
Enzymatically forming intranuclear peptide assemblies for selectively killing human induced pluripotent stem cells
Tumorigenic risk of undifferentiated human induced pluripotent stem cells (iPSCs), being a
major obstacle for clinical application of iPSCs, requires novel approaches for selectively …
major obstacle for clinical application of iPSCs, requires novel approaches for selectively …
Protease-responsive peptide-conjugated mitochondrial-targeting AIEgens for selective imaging and inhibition of SARS-CoV-2-infected cells
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a serious threat to
human health and lacks an effective treatment. There is an urgent need for both real-time …
human health and lacks an effective treatment. There is an urgent need for both real-time …
Magnetically induced brownian motion of iron oxide nanocages in alternating magnetic fields and their application for efficient SiRNA delivery
MA Kang, J Fang, A Paragodaarachchi, K Kodama… - Nano …, 2022 - ACS Publications
Hyperthermia of superparamagnetic nanoparticles driven by Néel relaxation in an
alternating magnetic field (AMF) has been studied in biomedical areas; however, Brownian …
alternating magnetic field (AMF) has been studied in biomedical areas; however, Brownian …
An Amphiphilic Cell‐Penetrating Macrocycle for Efficient Cytosolic Delivery of Proteins, DNA, and CRISPR Cas9
The discovery of safe platforms that can circumvent the endocytic pathway is of great
significance for biological therapeutics that are usually degraded during endocytosis. Here …
significance for biological therapeutics that are usually degraded during endocytosis. Here …
Alkaline Phosphatase Enabled Fluorogenic Reaction and in situ Coassembly of Near-Infrared and Radioactive Nanoparticles for in vivo Imaging
Y Hu, Y Miao, J Zhang, Y Chen, L Qiu, J Lin, D Ye - Nano Letters, 2021 - ACS Publications
Smart near-infrared (NIR) fluorescence (FL) and positron emission tomography (PET)
bimodal probes have shown promise for preoperative and intraoperative imaging of tumors …
bimodal probes have shown promise for preoperative and intraoperative imaging of tumors …
In situ stimulus-responsive self-assembled nanomaterials for drug delivery and disease treatment
Z Yan, Y Liu, L Zhao, J Hu, Y Du, X Peng, Z Liu - Materials Horizons, 2023 - pubs.rsc.org
The individual motifs that respond to specific stimuli for the self-assembly of nanomaterials
play important roles. In situ constructed nanomaterials are formed spontaneously without …
play important roles. In situ constructed nanomaterials are formed spontaneously without …
Cellular journey of nanomaterials: Theories, trafficking, and kinetics
Engineered nanomaterials (NMs) are increasingly fabricated in various fields involving
consumer goods, waste management, and biomedical applications such as drug delivery …
consumer goods, waste management, and biomedical applications such as drug delivery …