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Nuclear trafficking of the epidermal growth factor receptor family membrane proteins
Multiple membrane-bound receptor tyrosine kinases (RTKs), such as the epidermal growth
factor receptor (EGFR) and ErbB-2, have been reported to be localized in the nucleus …
factor receptor (EGFR) and ErbB-2, have been reported to be localized in the nucleus …
Proteolytic cleavage, trafficking, and functions of nuclear receptor tyrosine kinases
Intracellular localization has been reported for over three‐quarters of receptor tyrosine
kinase (RTK) families in response to environmental stimuli. Internalized RTK may bind to …
kinase (RTK) families in response to environmental stimuli. Internalized RTK may bind to …
Association of FGFR1 with ERα Maintains Ligand-Independent ER Transcription and Mediates Resistance to Estrogen Deprivation in ER+ Breast Cancer
Purpose: FGFR1 amplification occurs in approximately 15% of estrogen receptor–positive
(ER+) human breast cancers. We investigated mechanisms by which FGFR1 amplification …
(ER+) human breast cancers. We investigated mechanisms by which FGFR1 amplification …
Pigment epithelium-derived factor inhibits angiogenesis via regulated intracellular proteolysis of vascular endothelial growth factor receptor 1
Pigment epithelium-derived factor (PEDF) has been identified as one of the most potent of
endogenous negative regulators of blood vessel growth in the body. Here we report that …
endogenous negative regulators of blood vessel growth in the body. Here we report that …
FGFR1 cleavage and nuclear translocation regulates breast cancer cell behavior
AM Chioni, R Grose - Journal of cell biology, 2012 - rupress.org
FGF-10 and its receptors, FGFR1 and FGFR2, have been implicated in breast cancer
susceptibility and progression, suggesting that fibroblast growth factor (FGF) signaling may …
susceptibility and progression, suggesting that fibroblast growth factor (FGF) signaling may …
Nuclear translocation of cell‐surface receptors: lessons from fibroblast growth factor
The nuclear localization of a number of growth factors, cytokine ligands and their receptors
has been reported in various cell lines and tissues. These include members of the fibroblast …
has been reported in various cell lines and tissues. These include members of the fibroblast …
Physical and functional interactome atlas of human receptor tyrosine kinases
Much cell‐to‐cell communication is facilitated by cell surface receptor tyrosine kinases
(RTKs). These proteins phosphorylate their downstream cytoplasmic substrates in response …
(RTKs). These proteins phosphorylate their downstream cytoplasmic substrates in response …
Signaling, internalization, and intracellular activity of fibroblast growth factor
A Więdłocha, V Sørensen - Signalling from Internalized Growth Factor …, 2004 - Springer
Abstract The fibroblast growth factor (FGF) family contains 23 members in mammals
including its prototype members FGF-1 and FGF-2. FGFs have been implicated in regulation …
including its prototype members FGF-1 and FGF-2. FGFs have been implicated in regulation …
Integrative nuclear FGFR1 signaling (INFS) as a part of a universal “feed‐forward‐and‐gate” signaling module that controls cell growth and differentiation
MK Stachowiak, X Fang, JM Myers… - Journal of cellular …, 2003 - Wiley Online Library
A novel signaling mechanism is described through which extracellular signals and
intracellular signaling pathways regulate proliferation, growth, differentiation, and other …
intracellular signaling pathways regulate proliferation, growth, differentiation, and other …
Membrane-bound trafficking regulates nuclear transport of integral epidermal growth factor receptor (EGFR) and ErbB-2
Nuclear localization of multiple receptor-tyrosine kinases (RTKs), such as EGF receptor
(EGFR), ErbB-2, FGF receptor (FGFR), and many others, has been reported by several …
(EGFR), ErbB-2, FGF receptor (FGFR), and many others, has been reported by several …