Although directed migration of eukaryotic cells may have evolved to escape nutrient
depletion, it has been adopted for an extensive range of physiological events during …

Dissecting the intracellular signaling mechanisms that govern the movement of eukaryotic
cells presents a major challenge, not only because of the large number of molecular players …

Neutrophils and other amoeboid cells chemotax by steering their front ends towards
chemoattractant. Although Ras, Rac, Cdc42 and RhoA small GTPases all regulate …

Background Fish reproduction, development and growth are directly affected by
temperature, investigating the regulatory mechanisms behind high temperature stress is …

Mesenchymal cells such as fibroblasts are weakly polarized and reorient directionality by a
lamellipodial branching mechanism that is stabilized by phosphoinositide 3-kinase (PI3K) …

We model the motility of Dictyostelium cells in a systematic data-driven manner. We deduce
a minimal dynamical model that reproduces the statistical features of experimental …

Control of cell crawling behavior is fundamental to collective and concerted movements of
multiple cell types, as seen during embryonic development and physiological responses to …

The microenvironment determines cell behavior, but the underlying molecular mechanisms
are poorly understood because quantitative studies of cell signaling and behavior have …

Proper functioning of the innate immune response depends on migration of circulating
neutrophils into tissues at sites of infection and inflammation. Migration of highly motile …

Live-cell imaging can be used to capture spatio-temporal aspects of cellular responses that
are not accessible to fixed-cell imaging. As the use of live-cell imaging continues to …