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Neuronal maturation and axon regeneration: Unfixing circuitry to enable repair
Mammalian neurons lose the ability to regenerate their central nervous system axons as
they mature during embryonic or early postnatal development. Neuronal maturation requires …
they mature during embryonic or early postnatal development. Neuronal maturation requires …
Microenvironments‐Modulated Biomaterials Enhance Spinal Cord Injury Therapy
Y Li, Q Zhang, Z Liu, C Fu, J Ding - Advanced Functional …, 2024 - Wiley Online Library
Spinal cord injury (SCI) results from various causes, including sports‐related incidents,
degenerative cervical myelopathy, traffic accidents, and falls. SCI typically leads to sensory …
degenerative cervical myelopathy, traffic accidents, and falls. SCI typically leads to sensory …
Integrating hydrogels manipulate ECM deposition after spinal cord injury for specific neural reconnections via neuronal relays
Z Tan, L **ao, J Ma, K Shi, J Liu, F Feng, P **e… - Science …, 2024 - science.org
A bioinspired hydrogel composed of hyaluronic acid-graft-dopamine (HADA) and a designer
peptide HGF-(RADA) 4-DGDRGDS (HRR) was presented to enhance tissue integration …
peptide HGF-(RADA) 4-DGDRGDS (HRR) was presented to enhance tissue integration …
Single-cell and spatial atlases of spinal cord injury in the Tabulae Paralytica
Here, we introduce the Tabulae Paralytica—a compilation of four atlases of spinal cord
injury (SCI) comprising a single-nucleus transcriptome atlas of half a million cells, a …
injury (SCI) comprising a single-nucleus transcriptome atlas of half a million cells, a …
Low-cost and scalable projected light-sheet microscopy for the high-resolution imaging of cleared tissue and living samples
Light-sheet fluorescence microscopy (LSFM) is a widely used technique for imaging cleared
tissue and living samples. However, high-performance LSFM systems are typically …
tissue and living samples. However, high-performance LSFM systems are typically …
Caffeic acid phenethyl ester inhibits neuro-inflammation and oxidative stress following spinal cord injury by mitigating mitochondrial dysfunction via the SIRT1/PGC1α …
Y Zhang, Q Deng, H Hong, Z Qian, B Wan… - Journal of Translational …, 2024 - Springer
Background The treatment of spinal cord injury (SCI) has always been a significant research
focus of clinical neuroscience, with inhibition of microglia-mediated neuro-inflammation as …
focus of clinical neuroscience, with inhibition of microglia-mediated neuro-inflammation as …
Hypothalamic deep brain stimulation augments walking after spinal cord injury
A spinal cord injury (SCI) disrupts the neuronal projections from the brain to the region of the
spinal cord that produces walking, leading to various degrees of paralysis. Here, we aimed …
spinal cord that produces walking, leading to various degrees of paralysis. Here, we aimed …
Clickable, Thermally Responsive Hydrogels Enabled by Recombinant Spider Silk Protein and Spy Chemistry for Sustained Neurotrophin Delivery
The ability to deliver protein therapeutics in a minimally invasive, safe, and sustained
manner, without resorting to viral delivery systems, will be crucial for treating a wide range of …
manner, without resorting to viral delivery systems, will be crucial for treating a wide range of …
Biomimetic multichannel silk nerve conduits with multicellular spatiotemporal distributions for spinal cord injury repair
Bioengineered nerve conduits have shown great promise for spinal cord injury (SCI) repair,
while their practical values are limited by poor regenerative efficacy and lack of multi‐level …
while their practical values are limited by poor regenerative efficacy and lack of multi‐level …
A sequential stimuli-responsive hydrogel promotes structural and functional recovery of severe spinal cord injury
H Chen, W Wang, Y Yang, B Zhang, Z Li, L Chen, Q Tu… - Biomaterials, 2025 - Elsevier
Utilizing drug-loaded hydrogels to restore nerve conductivity emerges as a promising
strategy in the treatment of spinal cord injury (SCI). However, many of these hydrogels fail to …
strategy in the treatment of spinal cord injury (SCI). However, many of these hydrogels fail to …