Neuronal maturation and axon regeneration: Unfixing circuitry to enable repair

BJ Hilton, JM Griffin, JW Fawcett… - Nature Reviews …, 2024 - nature.com
Mammalian neurons lose the ability to regenerate their central nervous system axons as
they mature during embryonic or early postnatal development. Neuronal maturation requires …

Microenvironments‐Modulated Biomaterials Enhance Spinal Cord Injury Therapy

Y Li, Q Zhang, Z Liu, C Fu, J Ding - Advanced Functional …, 2024 - Wiley Online Library
Spinal cord injury (SCI) results from various causes, including sports‐related incidents,
degenerative cervical myelopathy, traffic accidents, and falls. SCI typically leads to sensory …

Integrating hydrogels manipulate ECM deposition after spinal cord injury for specific neural reconnections via neuronal relays

Z Tan, L **ao, J Ma, K Shi, J Liu, F Feng, P **e… - Science …, 2024 - science.org
A bioinspired hydrogel composed of hyaluronic acid-graft-dopamine (HADA) and a designer
peptide HGF-(RADA) 4-DGDRGDS (HRR) was presented to enhance tissue integration …

Single-cell and spatial atlases of spinal cord injury in the Tabulae Paralytica

MA Skinnider, M Gautier, AYY Teo, C Kathe, TH Hutson… - Nature, 2024 - nature.com
Here, we introduce the Tabulae Paralytica—a compilation of four atlases of spinal cord
injury (SCI) comprising a single-nucleus transcriptome atlas of half a million cells, a …

Low-cost and scalable projected light-sheet microscopy for the high-resolution imaging of cleared tissue and living samples

Y Chen, S Chauhan, C Gong, H Dayton, C Xu… - Nature Biomedical …, 2024 - nature.com
Light-sheet fluorescence microscopy (LSFM) is a widely used technique for imaging cleared
tissue and living samples. However, high-performance LSFM systems are typically …

Caffeic acid phenethyl ester inhibits neuro-inflammation and oxidative stress following spinal cord injury by mitigating mitochondrial dysfunction via the SIRT1/PGC1α …

Y Zhang, Q Deng, H Hong, Z Qian, B Wan… - Journal of Translational …, 2024 - Springer
Background The treatment of spinal cord injury (SCI) has always been a significant research
focus of clinical neuroscience, with inhibition of microglia-mediated neuro-inflammation as …

Hypothalamic deep brain stimulation augments walking after spinal cord injury

N Cho, JW Squair, V Aureli, ND James, L Bole-Feysot… - Nature medicine, 2024 - nature.com
A spinal cord injury (SCI) disrupts the neuronal projections from the brain to the region of the
spinal cord that produces walking, leading to various degrees of paralysis. Here, we aimed …

Clickable, Thermally Responsive Hydrogels Enabled by Recombinant Spider Silk Protein and Spy Chemistry for Sustained Neurotrophin Delivery

Y Li, C Yang, S Fang, Y Zhou, M Li, Z Liu… - Advanced …, 2024 - Wiley Online Library
The ability to deliver protein therapeutics in a minimally invasive, safe, and sustained
manner, without resorting to viral delivery systems, will be crucial for treating a wide range of …

Biomimetic multichannel silk nerve conduits with multicellular spatiotemporal distributions for spinal cord injury repair

T Yuan, W Li, M Zhou, X Wang, B Wang… - Advanced …, 2024 - Wiley Online Library
Bioengineered nerve conduits have shown great promise for spinal cord injury (SCI) repair,
while their practical values are limited by poor regenerative efficacy and lack of multi‐level …

A sequential stimuli-responsive hydrogel promotes structural and functional recovery of severe spinal cord injury

H Chen, W Wang, Y Yang, B Zhang, Z Li, L Chen, Q Tu… - Biomaterials, 2025 - Elsevier
Utilizing drug-loaded hydrogels to restore nerve conductivity emerges as a promising
strategy in the treatment of spinal cord injury (SCI). However, many of these hydrogels fail to …