Collagen breaks at weak sacrificial bonds taming its mechanoradicals

B Rennekamp, C Karfusehr, M Kurth, A Ünal… - Nature …, 2023 - nature.com
Collagen is a force-bearing, hierarchical structural protein important to all connective tissue.
In tendon collagen, high load even below macroscopic failure level creates …

Targeting cyclophilin A in the cardiac microenvironment preserves heart function and structure in failing hearts

M Sigle, AK Rohlfing, M Cruz Santos, T Kopp… - Circulation …, 2024 - ahajournals.org
BACKGROUND: Cardiac hypertrophy is characterized by remodeling of the myocardium,
which involves alterations in the ECM (extracellular matrix) and cardiomyocyte structure …

Investigating the effect of water on collagen triple helix stability

A Balupuri, DH Son, NS Kang - Journal of Molecular Liquids, 2024 - Elsevier
Collagen provides essential structural support to diverse body tissues through its unique
triple helix structure. Collagen stability is crucial for proper tissue function and any …

Single line of sight frame camera based on the RadOptic effect of ultrafast semiconductor detector

Y Liu, K He, X Yan, G Gao, W Du, Y Shang… - Optics and Lasers in …, 2024 - Elsevier
A new optical beam splitting method is proposed, based on which the optical frame camera
capable of capturing multiple frames in a single exposure is designed and experimentally …

The effect of pulling and twisting forces on chameleon sequence peptides

J Meadows, K Röder - ChemPhysChem, 2023 - Wiley Online Library
Chameleon sequences are amino acid sequences found in several distinct configurations in
experiment. They challenge our understanding of the link between sequence and structure …

Multi-Scale Simulations of Collagen Failure and Mechanoradicals

B Rennekamp - 2023 - archiv.ub.uni-heidelberg.de
Collagen, the most abundant protein in the human body, must withstand high mechanical
loads due to its structural role in tendons, skin, bones, and other connective tissue. It was …