Challenges of fluoride pollution in environment: mechanisms and pathological significance of toxicity–a review

S Wu, Y Wang, M Iqbal, K Mehmood, Y Li, Z Tang… - Environmental …, 2022 - Elsevier
Fluoride is an important trace element in the living body. A suitable amount of fluoride has a
beneficial effect on the body, but disproportionate fluoride entering the body will affect …

Role of ROS and RNS sources in physiological and pathological conditions

S Di Meo, TT Reed, P Venditti… - Oxidative medicine and …, 2016 - Wiley Online Library
There is significant evidence that, in living systems, free radicals and other reactive oxygen
and nitrogen species play a double role, because they can cause oxidative damage and …

Ferroptosis photoinduced by new cyclometalated iridium (III) complexes and its synergism with apoptosis in tumor cell inhibition

H Yuan, Z Han, Y Chen, F Qi, H Fang, Z Guo… - Angewandte …, 2021 - Wiley Online Library
Limited therapeutic efficacy to hypoxic and refractory solid tumors has hindered the practical
application of photodynamic therapy (PDT). Two new benzothiophenylisoquinoline (btiq) …

A rational design of metal–organic framework nanozyme with high-performance copper active centers for alleviating chemical corneal burns

Y Tang, Y Han, J Zhao, Y Lv, C Fan, L Zheng… - Nano-Micro Letters, 2023 - Springer
Metal–organic frameworks (MOFs) have attracted significant research interest in biomimetic
catalysis. However, the modulation of the activity of MOFs by precisely tuning the …

Mechanisms for modulating anoikis resistance in cancer and the relevance of metabolic reprogramming

FO Adeshakin, AO Adeshakin, LO Afolabi, D Yan… - Frontiers in …, 2021 - frontiersin.org
The attachment of cells to the extracellular matrix (ECM) is the hallmark of structure–function
stability and well-being. ECM detachment in localized tumors precedes abnormal …

[HTML][HTML] Green and cost-effective biofabrication of copper oxide nanoparticles: Exploring antimicrobial and anticancer applications

YT Gebreslassie, FG Gebremeskel - Biotechnology Reports, 2024 - Elsevier
Nanotechnology has made remarkable advancements in recent years, revolutionizing
various scientific fields, industries, and research institutions through the utilization of metal …

Brain-targeted codelivery of Bcl-2/Bcl-xl and Mcl-1 inhibitors by biomimetic nanoparticles for orthotopic glioblastoma therapy

W He, X Li, M Morsch, M Ismail, Y Liu, FU Rehman… - ACS …, 2022 - ACS Publications
Glioblastoma (GBM) is among the most treatment-resistant solid tumors and often recurrs
after resection. One of the mechanisms through which GBM escapes various treatment …

The mystery of BCL2 family: Bcl-2 proteins and apoptosis: an update

WA Siddiqui, A Ahad, H Ahsan - Archives of toxicology, 2015 - Springer
Apoptosis is a critically important biological process that plays an essential role in cell fate
and homeostasis. An important component of the apoptotic pathway is the family of proteins …

[HTML][HTML] Molecular targets of β-elemene, a herbal extract used in traditional Chinese medicine, and its potential role in cancer therapy: A review

B Zhai, N Zhang, X Han, Q Li, M Zhang, X Chen… - Biomedicine & …, 2019 - Elsevier
Abstract β-Elemene is a sesquiterpene compound extracted from the herb Curcuma
Rhizoma and is used in traditional Chinese medicine (TCM) to treat several types of cancer …

High mobility group box 1 (HMGB1): a pivotal regulator of hematopoietic malignancies

S Yuan, Z Liu, Z Xu, J Liu, J Zhang - Journal of Hematology & Oncology, 2020 - Springer
High mobility group box 1 (HMGB1) is a nonhistone chromatin-associated protein that has
been widely reported to play a pivotal role in the pathogenesis of hematopoietic …