Non-small-cell lung cancer
Non-small-cell lung cancer (NSCLC) is one of the most frequent cancer types and is
responsible for the majority of cancer-related deaths worldwide. The management of …
responsible for the majority of cancer-related deaths worldwide. The management of …
TRACERx analysis identifies a role for FAT1 in regulating chromosomal instability and whole-genome doubling via Hippo signalling
Chromosomal instability (CIN) is common in solid tumours and fuels evolutionary adaptation
and poor prognosis by increasing intratumour heterogeneity. Systematic characterization of …
and poor prognosis by increasing intratumour heterogeneity. Systematic characterization of …
Artificial intelligence-based biomarkers for treatment decisions in oncology
The development of new therapeutic strategies such as immune checkpoint inhibitors (ICIs)
and targeted therapies has increased the complexity of the treatment landscape for solid …
and targeted therapies has increased the complexity of the treatment landscape for solid …
Ongoing genome doubling promotes evolvability and immune dysregulation in ovarian cancer
Whole-genome doubling (WGD) is a critical driver of tumor development and is linked to
drug resistance and metastasis in solid malignancies. Here, we demonstrate that WGD is an …
drug resistance and metastasis in solid malignancies. Here, we demonstrate that WGD is an …
EGFR, TP53, and CUL3 Triple Mutation in Non‐Small Cell Lung Cancer and its Potentially Poor Prognosis: A Case Report and Database Analysis
H Hatano, T Yoshida, R Higashiyama… - Thoracic …, 2024 - Wiley Online Library
Concurrent mutations in tumor protein p53 (TP53) or Kelch‐like ECH‐associated protein 1‐
nuclear factor erythroid 2‐related factor 2‐pathway components are linked to poor outcomes …
nuclear factor erythroid 2‐related factor 2‐pathway components are linked to poor outcomes …
[HTML][HTML] Concurrent TP53 mutations facilitate resistance evolution in EGFR exon 20 S768I mutant lung adenocarcinoma: a case report and review of the literature
H Zhu, H Tang, H Peng, W Ding - Case Reports in Oncology, 2025 - karger.com
Introduction: Adenocarcinoma of the lung is the most common subtype of non-small cell lung
cancer, and epidermal growth factor receptor (EGFR) mutations are the most common driver …
cancer, and epidermal growth factor receptor (EGFR) mutations are the most common driver …
Predicting Personalised Therapeutic Combinations in Non-Small Cell Lung Cancer Using In Silico Modelling
The disease burden from non-small cell lung cancer (NSCLC) adenocarcinoma is
substantial, with around a million new cases diagnosed globally each year, and a 5-year …
substantial, with around a million new cases diagnosed globally each year, and a 5-year …
CDK4/6 and SHP2 mediate BRAF/MEK inhibitor resistance in Class 2 and 3 BRAF mutant cancers
Class 2 and 3 non-V600E BRAF mutations are oncogenic drivers in many cancer types.
Currently, there are no established targeted therapies with proven efficacy for cancers with …
Currently, there are no established targeted therapies with proven efficacy for cancers with …
Tobacco smoke alters the landscape of mutation, selection, and epistasis in lung adenocarcinoma
Tobacco smoke elevates mutagenesis. Its physiological effects may additionally influence
the adaptive benefits of specific mutations to oncogenesis. However, the relative …
the adaptive benefits of specific mutations to oncogenesis. However, the relative …
contribute to chromosomal instability in cancer cells
WT Lu, N Kanu - nature.com
FAT1 alterations contribute to chromosomal instability in cancer cells | Nature Cell Biology Skip
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