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Aducanumab and its effects on tau pathology: is this the turning point of amyloid hypothesis?
S Silvestro, A Valeri, E Mazzon - International Journal of Molecular …, 2022 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disorder affecting millions of people
around the world. The two main pathological mechanisms underlying the disease are beta …
around the world. The two main pathological mechanisms underlying the disease are beta …
Recent insights into the neurobiology of Alzheimer's disease and advanced treatment strategies
In recent years, significant advancements have been made in understanding Alzheimer's
disease from both neurobiological and clinical perspectives. Exploring the complex systems …
disease from both neurobiological and clinical perspectives. Exploring the complex systems …
Manipulation of the diet–microbiota–brain axis in Alzheimer's disease
Several studies investigating the pathogenesis of Alzheimer's disease have identified
various interdependent constituents contributing to the exacerbation of the disease …
various interdependent constituents contributing to the exacerbation of the disease …
What have we learned from past failures of investigational drugs for Alzheimer's disease?
BP Imbimbo, M Watling - Expert Opinion on Investigational Drugs, 2021 - Taylor & Francis
Introduction In the last 15 years, huge efforts against Alzheimer's disease (AD) with drugs
targeting β-amyloid (Aβ) and tau have produced poor clinical results. Aducanumab, a …
targeting β-amyloid (Aβ) and tau have produced poor clinical results. Aducanumab, a …
Design, synthesis, and in vitro and in vivo characterization of new memantine analogs for Alzheimer's disease
AL Turcu, J Companys-Alemany, MB Phillips… - European journal of …, 2022 - Elsevier
Currently, of the few accessible symptomatic therapies for Alzheimer's disease (AD),
memantine is the only N-methyl-d-aspartate receptor (NMDAR) blocker approved by the …
memantine is the only N-methyl-d-aspartate receptor (NMDAR) blocker approved by the …
Auditory gamma-band entrainment enhances default mode network connectivity in dementia patients
Dementia, and in particular Alzheimer's disease (AD), can be characterized by disrupted
functional connectivity in the brain caused by beta-amyloid deposition in neural links. Non …
functional connectivity in the brain caused by beta-amyloid deposition in neural links. Non …
A feasibility study of AlzLife 40 Hz sensory therapy in patients with MCI and early AD
SD McNett, A Vyshedskiy, A Savchenko, D Durakovic… - Healthcare, 2023 - mdpi.com
Alzheimer's Disease (AD) and Mild Cognitive Impairment (MCI) are debilitating diseases that
affect millions of individuals and have notoriously limited treatment options. One emerging …
affect millions of individuals and have notoriously limited treatment options. One emerging …
Exploring the impact of 40 Hz multi-luminaire light exposure in Alzheimer's dementia: insights from a convenient sampling, non-randomized case–control study
KY Li, CF Chien, LC Huang, K Lim, YH Yang - Journal of Neurology, 2024 - Springer
Abstract Background Recent studies propose 40 Hz neural activity induction as a promising
approach for managing Alzheimer's dementia (AD). However, traditional flickering light is …
approach for managing Alzheimer's dementia (AD). However, traditional flickering light is …
Treatment of Alzheimer disease
Alzheimer disease (AD) is a neurodegenerative disorder that primarily affects older adults
and is the most common cause of dementia. The most essential and often earliest clinical …
and is the most common cause of dementia. The most essential and often earliest clinical …
Practical Considerations in the Administration of Aducanumab for the Neurologist
K Coerver, MM Yu, A D'Abreu… - Neurology: Clinical …, 2022 - AAN Enterprises
Aducanumab (Aduhelm), developed by the biotechnology firm Biogen in Cambridge, MA,
was approved using the less common accelerated approval pathway by the Federal Drug …
was approved using the less common accelerated approval pathway by the Federal Drug …