Aducanumab and its effects on tau pathology: is this the turning point of amyloid hypothesis?

S Silvestro, A Valeri, E Mazzon - International Journal of Molecular …, 2022 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disorder affecting millions of people
around the world. The two main pathological mechanisms underlying the disease are beta …

Recent insights into the neurobiology of Alzheimer's disease and advanced treatment strategies

K Anitha, MK Singh, K Kohat, S Chenchula… - Molecular …, 2024 - Springer
In recent years, significant advancements have been made in understanding Alzheimer's
disease from both neurobiological and clinical perspectives. Exploring the complex systems …

Manipulation of the diet–microbiota–brain axis in Alzheimer's disease

D Lee, VMY Lee, SK Hur - Frontiers in Neuroscience, 2022 - frontiersin.org
Several studies investigating the pathogenesis of Alzheimer's disease have identified
various interdependent constituents contributing to the exacerbation of the disease …

What have we learned from past failures of investigational drugs for Alzheimer's disease?

BP Imbimbo, M Watling - Expert Opinion on Investigational Drugs, 2021 - Taylor & Francis
Introduction In the last 15 years, huge efforts against Alzheimer's disease (AD) with drugs
targeting β-amyloid (Aβ) and tau have produced poor clinical results. Aducanumab, a …

Design, synthesis, and in vitro and in vivo characterization of new memantine analogs for Alzheimer's disease

AL Turcu, J Companys-Alemany, MB Phillips… - European journal of …, 2022 - Elsevier
Currently, of the few accessible symptomatic therapies for Alzheimer's disease (AD),
memantine is the only N-methyl-d-aspartate receptor (NMDAR) blocker approved by the …

Auditory gamma-band entrainment enhances default mode network connectivity in dementia patients

M Lahijanian, H Aghajan, Z Vahabi - Scientific Reports, 2024 - nature.com
Dementia, and in particular Alzheimer's disease (AD), can be characterized by disrupted
functional connectivity in the brain caused by beta-amyloid deposition in neural links. Non …

A feasibility study of AlzLife 40 Hz sensory therapy in patients with MCI and early AD

SD McNett, A Vyshedskiy, A Savchenko, D Durakovic… - Healthcare, 2023 - mdpi.com
Alzheimer's Disease (AD) and Mild Cognitive Impairment (MCI) are debilitating diseases that
affect millions of individuals and have notoriously limited treatment options. One emerging …

Exploring the impact of 40 Hz multi-luminaire light exposure in Alzheimer's dementia: insights from a convenient sampling, non-randomized case–control study

KY Li, CF Chien, LC Huang, K Lim, YH Yang - Journal of Neurology, 2024 - Springer
Abstract Background Recent studies propose 40 Hz neural activity induction as a promising
approach for managing Alzheimer's dementia (AD). However, traditional flickering light is …

Treatment of Alzheimer disease

D Press, SS Buss - U: UpToDate, Barbieri RL ed. UpToDate [Internet] …, 2021 - uptodate.com
Alzheimer disease (AD) is a neurodegenerative disorder that primarily affects older adults
and is the most common cause of dementia. The most essential and often earliest clinical …

Practical Considerations in the Administration of Aducanumab for the Neurologist

K Coerver, MM Yu, A D'Abreu… - Neurology: Clinical …, 2022 - AAN Enterprises
Aducanumab (Aduhelm), developed by the biotechnology firm Biogen in Cambridge, MA,
was approved using the less common accelerated approval pathway by the Federal Drug …