Complex multicellular organisms, such as mammals, express two complete sets of
chromosomes per nucleus, combining the genetic material of both parents. However …

There is increasing evidence in humans and laboratory animals for biologically based sex
differences in every phase of drug addiction: acute reinforcing effects, transition from …

INTRODUCTION A mechanistic understanding of brain function requires the identification of
distinct cell types in the brain at a molecular, spatial, and functional level. The preoptic …

Expression from both alleles is generally observed in analyses of diploid cell populations,
but studies addressing allelic expression patterns genome-wide in single cells are lacking …

Oral cancer (OC) is among the most common malignancies in the world. Despite advances
in therapy, the worst-case scenario for OC remains metastasis, with a 50% survival rate …

Sex/Gender presents a relatively new way to think about how biological difference can be
produced over time in response to different environmental and social experiences. This …

Highly multiplexed single-molecule FISH has emerged as a promising approach to spatially
resolved single-cell transcriptomics because of its ability to directly image and profile …

The emerging awareness of the contribution of epigenetic processes to genome function in
health and disease is underpinned by decades of research in model systems. In particular …

It is known that information that is not contained in the DNA sequence—epigenetic
information—can be inherited from the parent to the offspring. However, many questions …

Differential methylation of the two parental genomes in placental mammals is essential for
genomic imprinting and embryogenesis. To systematically study this epigenetic process, we …