Basal cell carcinomas (BCCs) were essentially a molecular'black box'until some 12 years
ago, when identification of a genetic flaw in a rare subset of patients who have a great …

Common polymorphisms in DNA repair genes may alter protein function and an individual's
capacity to repair damaged DNA; deficits in repair capacity may lead to genetic instability …

An essential resource for all scientists researching cellular responses to DNA damage.•
Introduces important new material reflective of the major changes and developments that …

Two systems are essential in humans for genome integrity, DNA repair and apoptosis. Cells
that are defective in DNA repair tend to accumulate excess DNA damage. Cells defective in …

DNA repair genes have an important role in protecting individuals from cancer-causing
agents. Polymorphisms in several DNA repair genes have been identified and individuals …

In this marker evaluation study, we tested whether distinct patterns of functional genomic
polymorphisms in genes involved in drug metabolic pathways and DNA repair that predict …

Sequence variations have been identified in a number of DNA repair genes, including XPD,
but the effect of these polymorphisms on DNA repair capacity (DRC) is uncertain. We …

DNA, the genetic material in all living organisms, is continually exposed to agents that cause
damage to its structure, resulting in the loss of vital genetic information. To counteract the …

XPD codes for a DNA helicase involved in transcription and nucleotide excision repair. Rare
XPD mutations diminish nucleotide excision repair resulting in hypersensitivity to UV light …

Humans vary> 100-fold in their sensitivity to the harmful effects of ultraviolet radiation. The
main determinants of sensitivity are melanin pigmentation and less-well-characterized …