Roles for retrotransposon insertions in human disease
DC Hancks, HH Kazazian - Mobile DNA, 2016 - Springer
Over evolutionary time, the dynamic nature of a genome is driven, in part, by the activity of
transposable elements (TE) such as retrotransposons. On a shorter time scale it has been …
transposable elements (TE) such as retrotransposons. On a shorter time scale it has been …
The influence of LINE‐1 and SINE retrotransposons on mammalian genomes
Transposable elements (TEs) or “jum** genes” historically have been disparaged as a
class of “junk DNA” in mammalian genomes (1, 2). The advent of whole genome DNA …
class of “junk DNA” in mammalian genomes (1, 2). The advent of whole genome DNA …
Genome sequence of the Brown Norway rat yields insights into mammalian evolution
University of Utah Weiss Robert B. 14 Dunn Diane M … - Nature, 2004 - nature.com
The laboratory rat (Rattus norvegicus) is an indispensable tool in experimental medicine
and drug development, having made inestimable contributions to human health. We report …
and drug development, having made inestimable contributions to human health. We report …
Initial sequence of the chimpanzee genome and comparison with the human genome
… Sequencing and Analysis Consortium Waterson Robert … - Nature, 2005 - nature.com
Here we present a draft genome sequence of the common chimpanzee (Pan troglodytes).
Through comparison with the human genome, we have generated a largely complete …
Through comparison with the human genome, we have generated a largely complete …
Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and …
Objectives Completion of both the mouse and human genome sequences in the private and
public sectors has prompted comparison between the two species at multiple levels. This …
public sectors has prompted comparison between the two species at multiple levels. This …
LINE-1 elements in structural variation and disease
CR Beck, JL Garcia-Perez, RM Badge… - Annual review of …, 2011 - annualreviews.org
The completion of the human genome reference sequence ushered in a new era for the
study and discovery of human transposable elements. It now is undeniable that …
study and discovery of human transposable elements. It now is undeniable that …
A Map of the Interactome Network of the Metazoan C. elegans
To initiate studies on how protein-protein interaction (or “interactome”) networks relate to
multicellular functions, we have mapped a large fraction of the Caenorhabditis elegans …
multicellular functions, we have mapped a large fraction of the Caenorhabditis elegans …
Pseudogenes: pseudo-functional or key regulators in health and disease?
Pseudogenes have long been labeled as “junk” DNA, failed copies of genes that arise
during the evolution of genomes. However, recent results are challenging this moniker; …
during the evolution of genomes. However, recent results are challenging this moniker; …
Evaluation of candidate control genes for diagnosis and residual disease detection in leukemic patients using 'real-time'quantitative reverse-transcriptase polymerase …
E Beillard, N Pallisgaard, VHJ Van der Velden, W Bi… - Leukemia, 2003 - nature.com
Real-time quantitative RT-PCR (RQ-PCR) is a sensitive tool to monitor minimal residual
disease (MRD) in leukemic patients through the amplification of a fusion gene (FG) …
disease (MRD) in leukemic patients through the amplification of a fusion gene (FG) …
The GENCODE pseudogene resource
Background Pseudogenes have long been considered as nonfunctional genomic
sequences. However, recent evidence suggests that many of them might have some form of …
sequences. However, recent evidence suggests that many of them might have some form of …