Despite recent therapeutic advances in cancer treatment, metastasis remains the principal
cause of cancer death. Recent work has uncovered the unique biology of metastasis …

Metastatic progression combined with non-responsiveness towards systemic therapy often
shapes the course of disease for cancer patients and commonly determines its lethal …

Metastasis is initiated and sustained through therapy by cancer cells with stem-like and
immune-evasive properties, termed metastasis-initiating cells (MIC). Recent progress …

Catecholamines released by sympathetic nerves can activate adrenergic receptors present
on nearly every cell type, including myeloid-derived suppressor cells (MDSCs). Using in …

Fatty acid uptake and altered metabolism constitute hallmarks of metastasis,, yet evidence of
the underlying biology, as well as whether all dietary fatty acids are prometastatic, is lacking …

Heme, an iron-containing porphyrin, is of vital importance for cells due to its involvement in
several biological processes, including oxygen transport, energy production and drug …

Studies have reported the vital role of nerves in tumorigenesis and cancer progression.
Nerves infiltrate the tumor microenvironment thereby enhancing cancer growth and …

Recent studies have shown that peripheral nerves play an important role in the progression
of breast cancer. Breast cancer cells (BCCs) promote local peripheral nerve growth and …

Breast cancer diagnosis, surgery, adjuvant therapies and survivorship can all be extremely
stressful. In women, concerns about body image are common as a result of the disease and …

Nervous systems are traditionally thought of as providing sensing and behavioral
coordination functions at the level of the whole organism. What is the evolutionary origin of …