Cellular senescence is now considered an important driving mechanism for chronic lung
diseases, particularly chronic obstructive pulmonary disease (COPD) and idiopathic …

Human mesenchymal stem cells (MSCs) are primary multipotent cells capable of
differentiating into osteocytes, chondrocytes, and adipocytes when stimulated under …

During acute or chronic lung injury, inappropriate immune response and/or aberrant repair
process causes irreversible damage in lung tissue and most usually results in the …

Adult stem cells that are tightly regulated by the specific microenvironment, or the stem cell
niche, function to maintain tissue homeostasis and regeneration after damage. This …

Pulmonary fibrosis is a chronic and fatal lung disease that significantly impacts the aging
population globally. To date, anti-fibrotic, immunosuppressive, and other adjunct therapy …

Aging is an inevitable and complex natural phenomenon due to the increase in age. Cellular
senescence means a non-proliferative but viable cellular physiological state. It is the basis of …

Simple Summary Aging and frailty are complex processes implicating multifactorial
mechanisms, which demand for new therapeutic strategies against their devastating effects …

Idiopathic pulmonary fibrosis (IPF) is a progressive fatal lung disorder with an unknown
etiology and very limited therapeutic options. The incidence and severity of IPF increase with …

Inflammatory bowel diseases (IBD) are an example of chronic diseases affecting 40% of the
population, which involved tissue damage and an inflammatory process not satisfactorily …

Acute respiratory distress syndrome (ARDS) represents a current challenge for medicine
due to its incidence, morbidity and mortality and, also, the absence of an optimal treatment …