The multifaceted role of kinases in amyotrophic lateral sclerosis: genetic, pathological and therapeutic implications
Amyotrophic lateral sclerosis is the most common degenerative disorder of motor neurons in
adults. As there is no cure, thousands of individuals who are alive at present will succumb to …
adults. As there is no cure, thousands of individuals who are alive at present will succumb to …
Injury-specific factors in the cerebrospinal fluid regulate astrocyte plasticity in the human brain
S Sirko, C Schichor, P Della Vecchia, F Metzger… - Nature Medicine, 2023 - nature.com
The glial environment influences neurological disease progression, yet much of our
knowledge still relies on preclinical animal studies, especially regarding astrocyte …
knowledge still relies on preclinical animal studies, especially regarding astrocyte …
Cerebrovascular anomalies: perspectives from immunology and cerebrospinal fluid flow
Appropriate vascular function is essential for the maintenance of central nervous system
homeostasis and is achieved through virtue of the blood-brain barrier; a specialized …
homeostasis and is achieved through virtue of the blood-brain barrier; a specialized …
Neuroinflammation plays a critical role in cerebral cavernous malformation disease
CC Lai, B Nelsen, E Frias-Anaya… - Circulation …, 2022 - Am Heart Assoc
Background: Cerebral cavernous malformations (CCMs) are neurovascular lesions caused
by loss of function mutations in 1 of 3 genes, including KRIT1 (CCM1), CCM2, and PDCD10 …
by loss of function mutations in 1 of 3 genes, including KRIT1 (CCM1), CCM2, and PDCD10 …
Identification of novel proteins for lacunar stroke by integrating genome-wide association data and human brain proteomes
C Zhang, F Qin, X Li, X Du, T Li - BMC medicine, 2022 - Springer
Background Previous genome-wide association studies (GWAS) have identified numerous
risk genes for lacunar stroke, but it is challenging to decipher how they confer risk for the …
risk genes for lacunar stroke, but it is challenging to decipher how they confer risk for the …
[HTML][HTML] Transcriptome analysis provides new molecular signatures in sporadic Cerebral Cavernous Malformation endothelial cells
C Scimone, L Donato, S Alibrandi, T Esposito… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Cerebral cavernous malformations (CCM) are lesions affecting brain capillaries that appear
with a mulberry-like morphology. This shape results from the enlarged and tangled …
with a mulberry-like morphology. This shape results from the enlarged and tangled …
[HTML][HTML] The multifaceted PDCD10/CCM3 gene
The programmed cell death 10 (PDCD10) gene was originally identified as an apoptosis-
related gene, although it is now usually known as CCM3, as the third causative gene of …
related gene, although it is now usually known as CCM3, as the third causative gene of …
Roles of Cullin-RING ubiquitin ligases in cardiovascular diseases
Maintenance of protein homeostasis is crucial for virtually every aspect of eukaryotic biology.
The ubiquitin-proteasome system (UPS) represents a highly regulated quality control …
The ubiquitin-proteasome system (UPS) represents a highly regulated quality control …
Inflammation and neutrophil extracellular traps in cerebral cavernous malformation
Abstract Cerebral Cavernous Malformation (CCM) is a brain vascular disease with various
neurological symptoms. In this study, we describe the inflammatory profile in CCM and show …
neurological symptoms. In this study, we describe the inflammatory profile in CCM and show …
Pharmacological blocking of neutrophil extracellular traps attenuates immunothrombosis and neuroinflammation in cerebral cavernous malformation
FC Onyeogaziri, R Smith, M Arce, H Huang… - Nature cardiovascular …, 2024 - nature.com
Cerebral cavernous malformation (CCM) is a neurovascular disease with symptoms such as
strokes, hemorrhages and neurological deficits. With surgery being the only treatment …
strokes, hemorrhages and neurological deficits. With surgery being the only treatment …