Cell cycle control in cancer
Cancer is a group of diseases in which cells divide continuously and excessively. Cell
division is tightly regulated by multiple evolutionarily conserved cell cycle control …
division is tightly regulated by multiple evolutionarily conserved cell cycle control …
Physiological functions and roles in cancer of the proliferation marker Ki-67
N Andrés-Sánchez, D Fisher… - Journal of Cell …, 2022 - journals.biologists.com
What do we know about Ki-67, apart from its usefulness as a cell proliferation biomarker in
histopathology? Discovered in 1983, the protein and its regulation of expression and …
histopathology? Discovered in 1983, the protein and its regulation of expression and …
Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle plasticity
CDK2 is a core cell-cycle kinase that phosphorylates many substrates to drive progression
through the cell cycle. CDK2 is hyperactivated in multiple cancers and is therefore an …
through the cell cycle. CDK2 is hyperactivated in multiple cancers and is therefore an …
Loss of CDK4/6 activity in S/G2 phase leads to cell cycle reversal
In mammalian cells, the decision to proliferate is thought to be irreversibly made at the
restriction point of the cell cycle,, when mitogen signalling engages a positive feedback loop …
restriction point of the cell cycle,, when mitogen signalling engages a positive feedback loop …
Genetic instability from a single S phase after whole-genome duplication
Diploid and stable karyotypes are associated with health and fitness in animals. By contrast,
whole-genome duplications—doublings of the entire complement of chromosomes—are …
whole-genome duplications—doublings of the entire complement of chromosomes—are …
A cyclin-dependent kinase-mediated phosphorylation switch of disordered protein condensation
JM Valverde, G Dubra, M Phillips, A Haider… - Nature …, 2023 - nature.com
Cell cycle transitions result from global changes in protein phosphorylation states triggered
by cyclin-dependent kinases (CDKs). To understand how this complexity produces an …
by cyclin-dependent kinases (CDKs). To understand how this complexity produces an …
Core control principles of the eukaryotic cell cycle
Cyclin-dependent kinases (CDKs) lie at the heart of eukaryotic cell cycle control, with
different cyclin–CDK complexes initiating DNA replication (S-CDKs) and mitosis (M-CDKs) …
different cyclin–CDK complexes initiating DNA replication (S-CDKs) and mitosis (M-CDKs) …
PP2A-B55: substrates and regulators in the control of cellular functions
P Amin, S Awal, S Vigneron, S Roque, F Mechali… - Oncogene, 2022 - nature.com
PP2A is a major serine/threonine phosphatase class involved in the regulation of cell
signaling through the removal of protein phosphorylation. This class of phosphatases is …
signaling through the removal of protein phosphorylation. This class of phosphatases is …
Positively charged specificity site in cyclin B1 is essential for mitotic fidelity
C Heinzle, A Höfler, J Yu, P Heid, N Kremer… - Nature …, 2025 - nature.com
Phosphorylation of substrates by cyclin-dependent kinases (CDKs) is the driving force of cell
cycle progression. Several CDK-activating cyclins are involved, yet how they contribute to …
cycle progression. Several CDK-activating cyclins are involved, yet how they contribute to …
Rapid and specific degradation of endogenous proteins in mouse models using auxin-inducible degrons
L Macdonald, GC Taylor, JM Brisbane, E Christodoulou… - Elife, 2022 - elifesciences.org
Auxin-inducible degrons are a chemical genetic tool for targeted protein degradation and
are widely used to study protein function in cultured mammalian cells. Here, we develop …
are widely used to study protein function in cultured mammalian cells. Here, we develop …