The origin and biomedical relevance of cannabigerol

A Jastrząb, I Jarocka-Karpowicz… - International journal of …, 2022 - mdpi.com
The constant search for new pharmacologically active compounds, especially those that do
not exhibit toxic effects, intensifies the interest in plant-based ingredients and their potential …

Cannabis sativa L. as a Natural Drug Meeting the Criteria of a Multitarget Approach to Treatment

A Stasiłowicz, A Tomala, I Podolak… - International journal of …, 2021 - mdpi.com
Cannabis sativa L. turned out to be a valuable source of chemical compounds of various
structures, showing pharmacological activity. The most important groups of compounds …

Phytocannabinoids in the pharmacotherapy of psoriasis

A Wroński, I Jarocka-Karpowicz, A Stasiewicz… - Molecules, 2023 - mdpi.com
Phytocannabinoids are naturally occurring compounds, the main source of which is
Cannabis sativa L. Through direct action or interaction with G protein-coupled receptors …

Natural product-based pharmacological studies for neurological disorders

V Puri, N Kanojia, A Sharma, K Huanbutta… - Frontiers in …, 2022 - frontiersin.org
Central nervous system (CNS) disorders and diseases are expected to rise sharply in the
coming years, partly because of the world's aging population. Medicines for the treatment of …

Biosynthesis of phytocannabinoids and structural insights: a review

RK Govindarajan, AK Mishra, KH Cho, KH Kim… - Metabolites, 2023 - mdpi.com
Cannabis belongs to the family Cannabaceae, and phytocannabinoids are produced by the
Cannabis sativa L. plant. A long-standing debate regarding the plant is whether it contains …

Structural and functional insights into cannabinoid receptors

X Li, L Shen, T Hua, ZJ Liu - Trends in Pharmacological Sciences, 2020 - cell.com
Cannabinoid receptors type 1 (CB1) and 2 (CB2) are widely expressed in the human body,
and are attractive drug targets in the prevention and management of central nervous system …

Antimicrobial and Antiviral (SARS-CoV-2) Potential of Cannabinoids and Cannabis sativa: A Comprehensive Review

MS Mahmud, MS Hossain, ATMF Ahmed, MZ Islam… - Molecules, 2021 - mdpi.com
Antimicrobial resistance has emerged as a global health crisis and, therefore, new drug
discovery is a paramount need. Cannabis sativa contains hundreds of chemical constituents …

Therapeutic considerations of bioactive compounds in Alzheimer's disease and Parkinson's disease: Dissecting the molecular pathways

BC Phukan, R Roy, I Gahatraj… - Phytotherapy …, 2023 - Wiley Online Library
Leading neurodegenerative diseases Alzheimer's disease (AD) and Parkinson's disease
(PD) are characterized by the impairment of memory and motor functions, respectively …

Attenuation of oxidative stress by cannabinoids and cannabis extracts in differentiated neuronal cells

A Raja, S Ahmadi, F de Costa, N Li, K Kerman - Pharmaceuticals, 2020 - mdpi.com
In this proof-of-concept study, the antioxidant activity of phytocannabinoids, namely
cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC), were investigated using an in vitro …

The biochemistry of phytocannabinoids and metabolic engineering of their production in heterologous systems

K Blatt-Janmaat, Y Qu - International Journal of Molecular Sciences, 2021 - mdpi.com
The medicinal properties of cannabis and the its legal status in several countries and
jurisdictions has spurred the massive growth of the cannabis economy around the globe …