The historic term 'histiocytosis' meaning 'tissue cell'is used as a unifying concept for
diseases characterized by pathogenic myeloid cells that share histological features with …

Langerhans cell histiocytosis (LCH) is caused by clonal expansion of myeloid precursors
that differentiate into CD1a+/CD207+ cells in lesions that leads to a spectrum of organ …

Langerhans-Cell Histiocytosis A spectrum of diseases formerly known as histiocytosis X and
now called Langerhans-cell histiocytosis is characterized by ERK pathway activation …

Neurodegenerative diseases (ND) are characterized by progressive loss of neuronal
function. Mechanisms of ND pathogenesis are incompletely understood, hampering the …

Abstract Langerhans Cell Histiocytosis (LCH) is an orphan disease of clonal dendritic cells
which may affect any organ of the body. Most of the knowledge about the diagnosis and …

Lesions of the cerebral white matter (WM) result in focal neurobehavioral syndromes,
neuropsychiatric phenomena, and dementia. The cerebral WM contains fiber pathways that …

Histiocytoses are disorders characterised by inflammation and the accumulation of cells
derived from the monocyte and macrophage lineages, which results in tissue damage …

Langerhans cell histiocytosis is a rare clonal disease characterized by the proliferation of
CD1a-positive immature dendritic cells. The purpose of this article was to present an …

Langerhans cell histiocytosis (LCH) is a rare disease of the monocyte-macrophage system.
The clinical presentation ranges from a single bone lesion to widespread multiorgan …

Histiocytic neoplasms are rare hematologic disorders accounting for less than 1% of cancers
of the soft tissue and lymph nodes. Clinical presentation and prognosis of these disorders …