Cancer is characterized by abnormal cell differentiation in or on the part of the body. The
most commonly used chemotherapeutic drugs are developed to target rapidly dividing cells …

There is a molecular coupling between neurodegenerative diseases, including
glaucomatous neurodegeneration (GN), Alzheimer's disease (AD), and Parkinson's disease …

Target-based discovery of first-in-class therapeutics demands an in-depth understanding of
the molecular mechanisms underlying human diseases. Precise measurements of cellular …

The L-type Ca2+ channel (CaV1. 2) is essential for cardiac excitation–contraction coupling.
To contribute to the inward Ca2+ flux that drives Ca2+-induced-Ca2+-release, CaV1. 2 …

The transcriptional activity of Forkhead Box O3 (FOXO3a) is inactivated by AKT-mediated
phosphorylation on Serine 253 (S253), which enables FOXO3a binding to 14-3-3 …

Due to its role in apoptosis, differentiation, cell cycle arrest, and DNA damage repair in
stress responses (oxidative stress, hypoxia, chemotherapeutic drugs, and UV irradiation or …

To target benign prostatic hyperplasia (BPH) as a common urinary disease in old men, in the
current study, the antiproliferative and apoptotic mechanism of SH‐PRO, a mixture of …

Ashok Venkitaraman has made seminal discoveries elucidating the tumour suppressive
mechanisms that maintain genome integrity through his pivotal studies on the breast cancer …