Structural information on helicase proteins has expanded recently beyond the DNA
helicases Rep and PcrA, and the hepatitis C virus RNA helicase to include UvrB, members …

DNA is the molecule chosen by nature to store the information required to build organisms.
These organisms in turn serve to replicate that information. It was initially thought that DNA …

We have determined two different structures of PcrA DNA helicase complexed with the same
single strand tailed DNA duplex, providing snapshots of different steps on the catalytic …

Bloom's syndrome (BS) is an autosomal recessive disorder associated with dwarfism,
immunodeficiency, reduced fertility, and elevated levels of many types of cancer. BS cells …

The stalling of DNA replication forks that occurs as a consequence of encountering DNA
damage is a critical problem for cells. RecG protein is involved in the processing of stalled …

In bacteria, one of the major transcriptional termination mechanisms requires a RNA/DNA
helicase known as the Rho factor. We have determined two structures of Rho complexed …

Since the discovery of the DNA double helix, there has been a fascination in understanding
the molecular mechanisms and cellular processes that account for:(i) the transmission of …

Helicase-dependent amplification (HDA) is an isothermal in vitro DNA amplification method
based upon the coordinated actions of helicases to separate double-stranded DNA and …

The family of nucleic acid (NA) strand separation enzymes known as helicases are found in
all organisms and participate in a wide variety of cellular processes. The central reaction …

The Ded1 protein (Ded1p), a member of the DEAD-box family, has recently been shown to
be essential for translation initiation in Saccharomyces cerevisiae. Here, we show that …