Background: The development of radiopharmaceuticals containing 225Ac for targeted alpha
therapy is an active area of academic and commercial research worldwide. Objectives …

Abstract Development of novel imaging probes for cancer diagnosis is critical for early
disease detection and management. The past two decades have witnessed a surge in the …

The α-emitting radionuclide actinium-225 possesses nuclear properties that are highly
promising for use in targeted α therapy (TAT), a therapeutic strategy that employs α particle …

Despite the current progresses of modern medicine, the resistance of malignant tumors to
present medical treatments points to the necessity of develo** new therapeutic …

Background In the past years, there has been a notable increase in interest regarding
targeted alpha therapy using Ac-225, driven by the observed promising clinical anti-tumor …

Targeted alpha-particle therapy (TAT) aims to selectively deliver radionuclides emitting α-
particles (cytotoxic payload) to tumors by chelation to monoclonal antibodies, peptides or …

Background Radiation nanomedicines are nanoparticles labeled with radionuclides that
emit α-or β-particles or Auger electrons for cancer treatment. We describe here our 15 years …

In the last two decades, various nanomaterials have attracted increasing attention in medical
science owing to their unique physical and chemical characteristics. Incorporating …

Cancer, one of the leading causes of death worldwide, remains a challenge to treat. Over
the last decades, targeted therapies have emerged as a way to selectively target and treat …

Recent advances in the field of nanotechnology application in nuclear medicine offer the
promise of better therapeutic options. In recent years, increasing efforts have been made on …