DNA replication and RNA transcription processes compete for the same DNA template and,
thus, frequently collide. These transcription–replication collisions are thought to lead to …

Human development relies on the correct replication, maintenance and segregation of our
genetic blueprints. How these processes are monitored across embryonic lineages, and why …

Mammalian DNA replication origins have been historically difficult to identify and their
determinants are still unresolved. Here, we first review methods developed over the last …

From the preservation of genomic integrity to the regulation of RNA translation, nearly all
cellular processes are regulated in a cell context-dependent manner. To fully understand the …

DNA replication ensures the precise transmission of genetic information from parent to
daughter cells. In eukaryotes, this process involves the replication of every base pair within a …

DNA replication, a fundamental process in all living organisms, proceeds with continuous
synthesis of the leading strand by DNA polymerase ε (Pol ε) and discontinuous synthesis of …

Replication forks encounter various impediments, which induce fork stalling and threaten
genome stability, yet the precise dynamics of fork stalling and restart at the single-cell level …

Dynamics of DNA replication speeds in single cells | Nature Reviews Molecular Cell Biology
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DNA replication initiates at genomic loci known as origins, which fire according to a
spatiotemporal program, still not yet well-defined in mammals. Here, we investigated …

Plasmodium species have variable genome compositions: many have an A/T-content of at
least 80% while others are similar in composition to human cells. Here, we made a direct …