Histone posttranslational modifications represent a versatile set of epigenetic marks
involved not only in dynamic cellular processes, such as transcription and DNA repair, but …

Since their discovery in the 1980s and 1990s, the human protein lysine acetyltransferase
encoded by the paralogous p300 and CBP genes has received much interest. p300/CBP …

The dynamic and reversible acetylation of proteins, catalysed by histone acetyltransferases
(HATs) and histone deacetylases (HDACs), is a major epigenetic regulatory mechanism of …

The acetyltransferases CBP and p300 are multifunctional transcriptional co-activators. Here,
we combined quantitative proteomics with CBP/p300-specific catalytic inhibitors …

Epigenetic and genetic alterations have long been thought of as two separate mechanisms
participating in carcinogenesis. A recent outcome of whole exome sequencing of thousands …

Simple Summary Through their regulatory effects on gene expression, histone
acetyltransferases have been implicated in the normal physiological activities and genesis …

ABSTRACT RUNX transcription factors orchestrate many different aspects of biology,
including basic cellular and developmental processes, stem cell biology and tumorigenesis …

RUNX proteins belong to a family of metazoan transcription factors that serve as master
regulators of development. They are frequently deregulated in human cancers, indicating a …

The bromodomain and extraterminal (BET) protein BRD4 is a validated drug target in
leukemia, yet its regulatory function in this disease is not well understood. Here, we show …

The enhancer factors CREB-binding protein (CBP) and p300 (also known as KAT3A and
KAT3B) maintain gene expression programs through lysine acetylation of chromatin and …