Liver immunology and its role in inflammation and homeostasis
The human liver is usually perceived as a non-immunological organ engaged primarily in
metabolic, nutrient storage and detoxification activities. However, we now know that the …
metabolic, nutrient storage and detoxification activities. However, we now know that the …
Immune surveillance by the liver
CN Jenne, P Kubes - Nature immunology, 2013 - nature.com
Receiving both portal vein blood and arterial blood, the liver is an important and critical
component in the defense against blood-borne infection. To accomplish this role, the liver …
component in the defense against blood-borne infection. To accomplish this role, the liver …
[HTML][HTML] Tumor-on-chip modeling of organ-specific cancer and metastasis
Every year, cancer claims millions of lives around the globe. Unfortunately, model systems
that accurately mimic human oncology–a requirement for the development of more effective …
that accurately mimic human oncology–a requirement for the development of more effective …
Molecular mechanisms underlying chemical liver injury
X Gu, JE Manautou - Expert reviews in molecular medicine, 2012 - cambridge.org
The liver is necessary for survival. Its strategic localisation, blood flow and prominent role in
the metabolism of xenobiotics render this organ particularly susceptible to injury by …
the metabolism of xenobiotics render this organ particularly susceptible to injury by …
IL-7 licenses activation of human liver intrasinusoidal mucosal-associated invariant T cells
Human mucosal-associated invariant T (MAIT) cells are a T cell population characterized by
the expression of a semi-invariant TCR capable of recognizing bacterial products in the …
the expression of a semi-invariant TCR capable of recognizing bacterial products in the …
Liver sinusoidal endothelial cells
KK Sørensen, J Simon‐Santamaria… - Comprehensive …, 2011 - Wiley Online Library
The liver sinusoidal endothelial cell (LSEC) forms the fenestrated wall of the hepatic
sinusoid and functions as a control post regulating and surveying the trafficking of molecules …
sinusoid and functions as a control post regulating and surveying the trafficking of molecules …
MicroRNAs transfer from human macrophages to hepato-carcinoma cells and inhibit proliferation
A Aucher, D Rudnicka, DM Davis - The Journal of Immunology, 2013 - journals.aai.org
Recent research has indicated a new mode of intercellular communication facilitated by the
movement of RNA between cells. There is evidence that RNA can transfer between cells in a …
movement of RNA between cells. There is evidence that RNA can transfer between cells in a …
Monitoring immune checkpoint regulators as predictive biomarkers in hepatocellular carcinoma
The global burden of hepatocellular carcinoma (HCC), one of the frequent causes of cancer-
related deaths worldwide, is rapidly increasing partly due to the limited treatment options …
related deaths worldwide, is rapidly increasing partly due to the limited treatment options …
The mechanism of anti-CD20–mediated B cell depletion revealed by intravital imaging
F Montalvao, Z Garcia, S Celli, B Breart… - The Journal of …, 2013 - Am Soc Clin Investig
Anti-CD20 Ab therapy has proven successful for treating B cell malignancies and a number
of autoimmune diseases. However, how anti-CD20 Abs operate in vivo to mediate B cell …
of autoimmune diseases. However, how anti-CD20 Abs operate in vivo to mediate B cell …
[HTML][HTML] Immune checkpoint inhibitors in hepatocellular cancer: current understanding on mechanisms of resistance and biomarkers of response to treatment
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy worldwide
and a leading cause of death worldwide. Its incidence continues to increase in the US due to …
and a leading cause of death worldwide. Its incidence continues to increase in the US due to …