The human liver is usually perceived as a non-immunological organ engaged primarily in
metabolic, nutrient storage and detoxification activities. However, we now know that the …

Receiving both portal vein blood and arterial blood, the liver is an important and critical
component in the defense against blood-borne infection. To accomplish this role, the liver …

Every year, cancer claims millions of lives around the globe. Unfortunately, model systems
that accurately mimic human oncology–a requirement for the development of more effective …

The liver is necessary for survival. Its strategic localisation, blood flow and prominent role in
the metabolism of xenobiotics render this organ particularly susceptible to injury by …

Human mucosal-associated invariant T (MAIT) cells are a T cell population characterized by
the expression of a semi-invariant TCR capable of recognizing bacterial products in the …

The liver sinusoidal endothelial cell (LSEC) forms the fenestrated wall of the hepatic
sinusoid and functions as a control post regulating and surveying the trafficking of molecules …

The increased production of derivatives of molecular oxygen and nitrogen in the form of
reactive oxygen species (ROS) and reactive nitrogen species (RNS) lead to molecular …

Recent research has indicated a new mode of intercellular communication facilitated by the
movement of RNA between cells. There is evidence that RNA can transfer between cells in a …

The global burden of hepatocellular carcinoma (HCC), one of the frequent causes of cancer-
related deaths worldwide, is rapidly increasing partly due to the limited treatment options …

Anti-CD20 Ab therapy has proven successful for treating B cell malignancies and a number
of autoimmune diseases. However, how anti-CD20 Abs operate in vivo to mediate B cell …