Pyroptosis, apoptosis, necroptosis, and ferroptosis, which are the most well-studied
regulated cell death (RCD) pathways, contribute to the clearance of infected or potentially …

Pulmonary epithelial cells are widely considered to be the first line of defence in the lung
and are responsible for coordinating the innate immune response to injury and subsequent …

The ancestral origins of the lytic cell death mode, necroptosis, lie in host defense. However,
the dysregulation of necroptosis in inflammatory diseases has led to widespread interest in …

Ovarian cancer (OC) is one of the most common malignancies that causes death in women
and is a heterogeneous disease with complex molecular and genetic changes. Because of …

Over the past few decades, mechanisms of programmed cell death have attracted the
scientific community because they are involved in diverse human diseases. Initially …

The pathophysiology of chronic obstructive pulmonary disease (COPD) and the undisputed
role of innate immune cells in this condition have dominated the field in the basic research …

Necroptosis, a distinctive type of programmed cell death different from apoptosis or necrosis,
triggered by a series of death receptors such as tumor necrosis factor receptor 1 (TNFR1) …

Background Environmental exposures are major risk factors for chronic obstructive
pulmonary disease (COPD). Ethylene oxide (EO) is a ubiquitous organic compound and …

Background Z-DNA binding protein 1 (ZBP1) is a vital innate immune sensor that regulates
inflammation during pathogen invasion. ZBP1 may contribute to pyroptosis, apoptosis and …

Despite global vaccination programs, infections with severe acute respiratory syndrome
coronavirus-2 (SARS-CoV-2) continue to cause severe disease with significant morbidity …